The Effect of Fibroblast Growth Factor and Cold Atmospheric Plasma Treatment on Calcaneus Tendon Healing Activity in Rabbits

Alireza Omranifard; Alireza Jahandideh; Ahmad Asghari; Saeed Hesaraki

doi:10.34172/cjmb.2023.32

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
The Effect of Fibroblast Growth Factor and Cold Atmospheric Plasma Treatment on Calcaneus Tendon Healing Activity in Rabbits
Alireza Omranifard¹, Alireza Jahandideh¹, Ahmad Asghari ¹, Saeed Hesaraki²
¹Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran ²Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
CJMB 2024; 11: 069-075 DOI: 10.34172/cjmb.2023.32 Viewed : 1756 times Downloaded : 2271 times. Keywords : Fibroblast growth factor, Cold atmospheric plasma, Hydroxyproline, Collagen, Reticulin, Histopathology, Tendon healing
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Abstract

Objectives: Tendon recovery after a surgical operation or traumatic injury is still one of the challenges of rehabilitation. Many recently formulated treatments have been designed to improve these procedures. This study aimed to evaluate the effects of recombinant basic fibroblast growth factor (bFGF) and cold atmospheric plasma (CAP) on calcaneus tendon healing and regeneration in rabbit models. Material and Methods: This study subdivided 40 mature male New Zealand white rabbits into four groups (n=10 in each). The defect was made under general conditions, and the wound was closed without treatment. The experimental groups included sham (without treatment), bFGF (operated bFGF in the injured area), CAP (used CAP in the injured area), and bFGF/CAP (used both CAP and bFGF) in the injured area. This study used trichrome and reticulin stains to evaluate collagen production and other tissue factors. Also, hydroxyproline levels were measured for better observation of collagen synthesis. Pathological evaluation of the defective tendon was performed on days 60 and 120 after surgery. Results: The improvement of new and parallel tendon formation was the best in the bFGF/CAP group at both times, especially 120 days after surgery. An increase in hydroxyproline levels was also seen on the sampling days. Conclusions: The experiment showed that bFGF/CAP combination significantly improved tendon remodeling in the injured areas.