|Chemolithotroph Bacteria: From Biology to Application in Medical Sciences|
|Elham Kazemi1, Saiedeh Razi Soofiyani2,3, Hossein Ahangari4, Shirin Eyvazi5, Mohammad Saeid Hejazi1,3, Vahideh Tarhriz3|
|1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
2Sina Educational Research, and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Food Science and Technology, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
CJMB 2021; 8: 081-089
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Keywords : Chemolithotroph bacteria, Secondary metabolites, Enzymes, Medical sciences
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Chemolithotrophs are specific bacteria that utilize inorganic compounds as their energy source. These bacteria as the main source of organic molecules have more advantages in various sciences. Unlike phototrophic and organotrophic bacteria which generate their energy via the fascination of sunlight or oxidation of complex organic molecules, chemolithotrophic bacteria can exploit unconventional sources of energy, including various industrial wastes . Therefore, chemolithotroph bacteria play a key role in the remediation of micropollutants such as synthetic hormones, pharmaceutical residues, and sanitary wastes. In addition, secondary metabolites including organic acids, enzymes, and antibiotics derived from these bacteria can be used as pharmaceutical compounds. It seems that the discovery and study of the novel chemolithotrophic bacteria and investigation of their features can be helpful in medical and pharmaceutical sciences. Accordingly, it was attempted to present a comprehensive review on chemolithotrophic microbes, their energy sources, and their applications.
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