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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2015, Vol 2, Issue 2
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Original Article
Study of the Resistance of Escherichia Coli Which Creates Community-Acquired Urinary Tract Infections to Ciprofloxacin and Co-Trimoxazole Antibiotics in Sari Hospitals, Iran
Roya Ghasemian1, Mehran Shokri2*, Atieh Makhlough3, Mandana Fallah3
1Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
3Department of Nephrology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

CJMB 2015; 2: 048-052

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Keywords : Antibiotic, Antimicrobial Resistance, Escherichia coli, Urinary Tract Infection
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Objective: Escherichia coli is the most important etiologic factor in urinary tract infection (UTI), which is becoming resistant to the common antibiotics. The aim of this study was to evaluate the resistance of this bacterium to the antibiotics that are commonly used.

Materials and Methods: A descriptive study conducted in patients with uncomplicated UTI referring to Sari hospitals during 2013-2014. For this purpose, samples that had positive urine culture were selected and evaluated with antibiogram. In addition, E-Test MIC method was used for antibiotics ciprofloxacin and co-trimoxazole. SPSS software was used for data analysis.

Results: Of the 101 patients studied, 83 (82.2%) were females and 18 (17.8%) were male. The mean age of patients was 40.32 ± 3.22 years. The most sensitivity was seen to nitrofurantoin (92.07%), gentamicin (76.23%). Most resistance was also seen to the antibiotics amoxicillin (74.25%), co-trimoxazole (64.35%) and ciprofloxacin (36.63%). In E-Test MIC method, 23.7% were resistant to the ciprofloxacin and 43.5% to co-trimoxazole.

Conclusion: Due to the high antibiotic resistance that was observed to ciprofloxacin and co-trimoxazole in this study, it seems a better alternative antibiotic such as nitrofurantoin should be used for the empirical treatment of patients with UTIs.


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