Study of the Resistance of Escherichia Coli Which Creates Community-Acquired Urinary Tract Infections to Ciprofloxacin and Co-Trimoxazole Antibiotics in Sari Hospitals, Iran

Roya Ghasemian; Mehran Shokri*; Atieh Makhlough; Mandana Fallah

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
Study of the Resistance of Escherichia Coli Which Creates Community-Acquired Urinary Tract Infections to Ciprofloxacin and Co-Trimoxazole Antibiotics in Sari Hospitals, Iran
Roya Ghasemian¹, Mehran Shokri²*, Atieh Makhlough³, Mandana Fallah³
¹Antimicrobial Resistance Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ²Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran ³Department of Nephrology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
CJMB 2015; 2: 048-052 Viewed : 3320 times Downloaded : 2280 times. Keywords : Antibiotic, Antimicrobial Resistance, Escherichia coli, Urinary Tract Infection
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Abstract

Objective: Escherichia coli is the most important etiologic factor in urinary tract infection (UTI), which is becoming resistant to the common antibiotics. The aim of this study was to evaluate the resistance of this bacterium to the antibiotics that are commonly used. Materials and Methods: A descriptive study conducted in patients with uncomplicated UTI referring to Sari hospitals during 2013-2014. For this purpose, samples that had positive urine culture were selected and evaluated with antibiogram. In addition, E-Test MIC method was used for antibiotics ciprofloxacin and co-trimoxazole. SPSS software was used for data analysis. Results: Of the 101 patients studied, 83 (82.2%) were females and 18 (17.8%) were male. The mean age of patients was 40.32 ± 3.22 years. The most sensitivity was seen to nitrofurantoin (92.07%), gentamicin (76.23%). Most resistance was also seen to the antibiotics amoxicillin (74.25%), co-trimoxazole (64.35%) and ciprofloxacin (36.63%). In E-Test MIC method, 23.7% were resistant to the ciprofloxacin and 43.5% to co-trimoxazole. Conclusion: Due to the high antibiotic resistance that was observed to ciprofloxacin and co-trimoxazole in this study, it seems a better alternative antibiotic such as nitrofurantoin should be used for the empirical treatment of patients with UTIs.