Comparison of Changes in Serum Creatinine and PNGAL in Predicting Renal Damage in Brucellosis Patients Receiving Gentamycin

Freidoon Poorshahbaz; Afsane Karami; Manigheh Jozpanahi; Ayyub Pezeshki; Sograt Fagihzadeh; Abdolreza Esmailzadeh; Rogayeh Moosazadeh; Mohammadreza Behmanesh; Mina Kiafar; Mahshid Kashkuli

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Oct 2015, Vol 2, Issue 4

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Original Article
Comparison of Changes in Serum Creatinine and PNGAL in Predicting Renal Damage in Brucellosis Patients Receiving Gentamycin
Freidoon Poorshahbaz¹, Afsane Karami¹, Manigheh Jozpanahi¹, Ayyub Pezeshki², Sograt Fagihzadeh³, Abdolreza Esmailzadeh⁴, Rogayeh Moosazadeh⁵, Mohammadreza Behmanesh⁶, Mina Kiafar⁶, Mahshid Kashkuli⁶
¹Department of Infectious Diseases and Tropical Medicine, Zanjan University of Medical Sciences, Zanjan, Iran ²Department of Nephrology, Zanjan University of Medical Sciences, Zanjan, Iran ³Department of Statistics, Zanjan University of Medical Sciences, Zanjan, Iran ⁴Department of Immunology, Zanjan University of Medical Sciences, Zanjan, Iran ⁵Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ⁶Department of Internal Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
CJMB 2015; 2: 116-120 Viewed : 3238 times Downloaded : 2852 times. Keywords : Serum neutrophil gelatinase-associated lipocalin, Acute kidney injury, Brucellosis, Gentamycin
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Abstract

Objective: Treatment with aminoglycosides is a preventable cause of acute kidney injury (AKI). Early predictive markers of AKI are crucial in preventing this condition. This study aimed to examine the role of serum neutrophil gelatinase-associated lipocalin (NGAL) level as a predictive marker of AKI in patients receiving gentamicin. Materials and Methods: In this prospective study, 37 patients with brucellosis (23 males, 14 females; mean age = 10.7 ± 33.7 years) were studied in a health center between March 2013 and March 2014. Serum creatinine and NGAL levels at baseline, and 3, 5 and 7 days after the administration of gentamicin were measured. In this study, a 25% increase in the serum creatinine levels compared with the baseline levels was considered a criterion for AKI risk. Results: The frequencies of patients prone to AKI at the first, third, fifth and seventh day of administration of gentamicin were 0%, 8.1%, 18.9%, and 13.5%, respectively. In total, 24.3% of the patients (n = 9) were prone to AKI. No statistically significant difference was observed between NGAL levels before and after the administration of gentamicin (P = .082). Conclusion: The serum NGAL level is not a sensitive and specific predictor of AKI following the administration of gentamicin. Therefore it is recommended to increase the frequency of sNGAL measurement and using more sensitive kits in more patients.