Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2017, Vol 4, Issue 3
Advanced Search
How do you find the scientific quality of the published articles on our web site?
Original Article
Comparison the Effect of Letrozole Versus Medroxy Progesterone Acetate on Premenopausal Patients With Endometrial Hyperplasia: An Randomized clinical trial
Elham Rahmani1, Shahnaz Ahmadi2, Niloofar Motamed3,4, Fatemeh Safinejad5
1Department of Gynecologic Obstetric, Bushehr University of Medical Sciences, Bushehr, Iran
2Department of Gynecologic Obstetric, Iran University of Medical Sciences, Tehran, Iran
3Department of Community Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4The Persian Gulf Nuclear Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
5Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran

CJMB 2017; 4: 099–103

Viewed : 1690 times
Downloaded : 1965 times.

Keywords : Letrozole, progesterone, endometrial hyperplasia, estradiol
Full Text(PDF) | Related Articles
Objective: The assessing the effect of letrozole and medroxyprogesterone acetate on women with simple endometrial hyperplasia without atypia in reproductive age.

Material and Methods: Eighty patients of Abolfazle clinic in Bushehr with abnormal uterine bleeding and simple endometrial hyperplasia enrolled in this study. The patients were randomized in 2 groups: group A included 40 patients who received 10 mg medroxyprogesterone acetate for 10 days in each month during 3 months and group B included 40 patient that received 2.5 mg letrozole for 3 months. Serial transvaginal sonography and estradiol were checked basically and repeated after 3 months of treatment. Main outcome measures were endometrial thickness and estradiol level in serum.

Result: In 2 groups A & B, there were no significant differences in the base variables. The level of estradiol in groups A and B before treatment was similar in the 2 groups. Endometrial thickness in groups A and B was not statistically significant. The difference between these 2 groups from the endometrial thickness reduction viewpoint, is not significant (P value = 0.445). The level of decline estradiol in serum in the groups A&B was significant,

Conclusion: Letrozole is an acceptable drug for treatment of simple endometrial hyperplasia especially in the patients who did not tolerate medroxyprogesterone.


Cite By, Google Scholar

Google Scholar

Articles by Rahmani E
Articles by Ahmadi S
Articles by Motamed N
Articles by 4 4
Articles by Safinejad F


Articles by Elham Rahmani
Articles by Shahnaz Ahmadi
Articles by 4

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Aras Part Medical International Press Editor-in-Chief
Arash Khaki
Deputy Editor
Zafer Akan
Published Article Statistics