Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats

Sara Parsania; Somaye Salehpoor; Maryam Sadrr Ameli; Morteza Abdi; Majid Shokoohi; Alireza Rahimi Mamaghani; Leila Majdi

doi:10.34172/cjmb.2024.3733

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats
Sara Parsania¹, Somaye Salehpoor², Maryam Sadrr Ameli³, Morteza Abdi⁴, Majid Shokoohi², Alireza Rahimi Mamaghani², Leila Majdi⁵
¹Department of Research and Development, Aras Part Medical Pharmacetical International Company, Tabriz, Iran ²Clinical Research Development Unit of Tabriz Vali Asr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran ³Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran ⁴Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ⁵Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
CJMB 2024; 11: 128-134 DOI: 10.34172/cjmb.2024.3733 Viewed : 1652 times Downloaded : 1808 times. Keywords : Testis, Hypoxia, Clove, Oxidative stress, Male fertility
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Abstract

Objectives: This study aims to comprehensively assess the therapeutic potential of clove extract in mitigating testicular damage and preserving male reproductive function under hypoxic conditions in male rats. Materials and Methods: We randomly divided 24 male rats into three groups: a hypoxia group that just received normal saline, a hypoxia + clove extract (4 mg/kg) group, and a sham operation group without treatment. After eight weeks, the serum level of oxidative stress parameters was examined, and the testicle histopathological examination, such as seminiferous tubule diameters and epithelium thickness, was assessed. Results: The serum malondialdehyde (MDA) concentration was significantly enhanced in the hypoxic group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) declined (P < 0.05). The diameters and thickness of the seminiferous tubule were diminished notably (P < 0.05). Johnson"s score decreased in the hypoxic group. Treatment with clove extract also led to improvements in this parameter. Conclusions: Our study provides compelling evidence for the therapeutic potential of clove extract in mitigating testicular injury associated with varicocele-induced testicular hypoxia in male rats.