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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2018, Vol 5, Issue 1
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Original Article
Effect of Intraoperative Dextrose Infusion for Prevention of Postoperative Nausea and Vomiting in Diagnostic Gynecologic Laparoscopy
Simin Atashkhoei1, Bahman Naghipour2, Pouya Hatami Marandi3, Abbasali Dehghani4, Hojjat Pourfathi5
1Department of Anesthesiology, Al-Zahra Hospital, Tabriz University of Medical Sciences, Iran
2Department of Anesthesiology, Fellowship of Cardiothoracic Anesthesiology, Shahid Madani Hospital,Tabriz,Iran.
3Faculty of Medicine, Tabriz University of Medical Sciences
4Department of Anesthesiology, Department of Anesthesiology, Imam Reza Hospital, Tabriz University of Medical Sciences, Iran
5Department of Anesthesiology, Taleghani Hospital,University of Medical Sciences,Tabriz, Iran

CJMB 2018; 5: 045-049

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Downloaded : 16775 times.

Keywords : Gynecologic laparoscopy, PONV, Prophylaxis, Dextrose
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Objective: Laparoscopic procedures are accompanied with a high occurrence of nausea and vomiting after surgery. This study aimed to evaluate the effectiveness of prophylactic intraoperative infusion of dextrose 5% in the avoidance of postoperative nausea and vomiting (PONV).

Materials and Methods: In this randomized, double-blind, placebo-controlled clinical trial, 70 ASA class I women, aged 20-40 years scheduled for diagnostic laparoscopy for infertility were studied. Following induction of anesthesia, study group (n = 35) received Ringer"s solution 10 mL/kg/h with glucose 500 mg/kg (dextrose 5%) and placebo group (n = 35) received Ringer"s solution with normal saline 0.9% in the same volume intraoperatively. The incidence and severity of PONV according to a 4-point scale (0-3) in the post-anesthesia care unit (PACU) and during the first 24 postoperative hours, the first request for antiemetic, and overall antiemetic consumption were compared between 2 groups.

Results: The overall incidence of PONV was certainly lower in the study group compared with the placebo group (22.85% vs. 45.71%; P = 0.03). Severity of PONV was significantly lower in the study group (1.14 ± 0.32) compared to the placebo group (2.50 ± 0.27) (P = 0.03). There was a statistically significant difference between 2 groups regarding the first request for antiemetic after surgery (7.1 ± 1.13 vs. 5.71 ± 1.76 hours, P = 0.04) and total dose of antiemetic (metoclopramide, 60 vs. 100 mg, P = 0.001). There was no significant difference in perioperative blood sugar levels between 2 groups (P = 0.46).

Conclusion: Intraoperative infusion of dextrose 5% was found to be an efficacious method in the prevention/reduction of PONV without any significant difference in postoperative blood sugar levels in patients undergoing diagnostic gynecologic laparoscopy.


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