Materials and Methods: In this descriptive cross-sectional study, , the data were collected using questionnaires of Sexual Quality of Life-Male (SQoL-M), Sexual Quality of Life-Female (SQoL-F), International Prostate Symptoms Score (IPSS), International Index of Erectile Function (IIEF), and Female Sexual Functional Index (FSFI). Multiple regression was performed using SPSS 20 software.

Results: The variables of IIEF Overall Satisfaction sub-score (IIEF-OS) (B=2.895, P<0.001), IIEF Erectile Function sub-score (IIEF-EF) (B=0.481, P<0.001), FSFI Pain sub-score (FSFI-P) (B=-2.348, P=0.001), male"s Financial situation (B=4.417 P=0.034), and disorder in male"s social life (B=5.553, P=0.013) were the final predictors of Men"s SQoL (R2=0.677, ADJ.R2=0.660, R=0.823). The variables of FSFI Satisfaction sub-score (FSFI-S) (B=9.223, P<0.001), FSFI-P (B=-1.696, P=0.028), and IIEF-OS (B=2.918, P=0.002) were the final predictors of their women"s SQoL (R2=0.724, ADJ.R2=0.716, R=0.851).

Conclusions: In sum, the negative effect of BPH on the SQoL of the couples was confirmed and variables such as the male"s financial situation from the socio-demographic factors, disorder in the male"s social life from the factors related to BPH and FSFI-P, IIEF-OS Along with IIEF-EF from the factors of related to the couple"s sexual function (FSFI and IIEF) were identified as the final predictors of Men"s SQoL. Also, the variables of FSFI-S, FSFI-P, and IIEF-OS from the factors of related to the couple"s sexual function (FSFI and IIEF) emerged as the final predictors of Women"s SQoL. Accordingly, the sexual function of the couples with BPH was identified as one of the final predictors of their SQoL. Therefore, proper counselling and increased sexual awareness among couples may have played an important role in improving the quality of their sexual lives. It was recommended that health policy makers should prioritize the significance of SQoL and its association with the overall health of the couples with BPH in educational programs.