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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2023, Vol 10, Issue 4
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The Association Between Helicobacter pylori Infection With Different Types of Colon Cancer and Children's Diseases: An Overview of Meta-analyses
Bahar Banasaz1, Sara Saadat2, Davood Kalantar-Neyestanaki3, Hossein Zarrinfar4, Fahimeh Shakeri5, Mahmood Barani6, Reza Mohammadinejad7, Firoozeh Mirzaee8, Masumeh Ghazanfarpour8
1Babol University of Medical Sciences, Babol, Iran
2Department of Pediatric, Division of Nephrology, Dr Sheikh Hospital, Mashhad University of Medical Sciences, Mashhad Iran
3Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran
4Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Medical Microbiology (Bacteriology and Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
7Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
8Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

CJMB 2023; 10: 153-160
DOI: 10.34172/cjmb.2023.29
Viewed : 1147 times
Downloaded : 1020 times.

Keywords : Helicobacter pylori infection, Colon cancer, Children, Meta-analysis
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Objectives: Helicobacter pylori is a gram-negative curved bacillus that assumes a significant role in colon cancer and children´s diseases. This study aimed to examine the association between H. pylori infection with colon cancer and children´s diseases in order to achieve a a comprehensive understanding of these associations and for future works.

Methods: Three main databases (i.e., Cochrane Central Register of Controlled Trials [CENTRAL], Scopus, and MEDLINE) were systematically searched by two reviewers from their inception date to 2022 in order to determine the association between the H. pylori infection with the colon cancer and children's diseases.

Results: The findings of two meta-analyses were similar regarding the positive association between the risks of colorectal neoplasm (pooled OR=0.18; 95% CI of 0.99–1.40; P > 0.05) and colon neoplasia (pooled OR=0.41; 95% confidence interval 1.24–1.60; P=0.000). H. pylori was associated with an increased risk of colorectal adenoma, adenocarcinoma, and advanced adenoma. Also H. pylori infection was correlated with a high risk of iron deficiency anemia (IDA), otitis media with effusion (OME), Henoch-Schonlein purpura, and growth disorders in children.

Conclusions: In sum, the H. pylori infection may have been associated with an increased risk of colorectal cancer and children's diseases.


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Articles by Banasaz B
Articles by Saadat S
Articles by Zarrinfar H
Articles by Shakeri F
Articles by Barani M
Articles by Mohammadinejad R
Articles by Mirzaee F
Articles by Ghazanfarpour M


Articles by Bahar Banasaz
Articles by Sara Saadat
Articles by Hossein Zarrinfar
Articles by Fahimeh Shakeri
Articles by Mahmood Barani
Articles by Firoozeh Mirzaee

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