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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2023, Vol 10, Issue 3
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Original Article
The Effect of Carvacrol Plus Treadmill Exercise on Testis Structure and Oxidative Stress in Streptozotocin-Induced Diabetic Rats
Ramesh Bradaran Bagheri1, Jamal Shadman2, Amir Afshin Khaki3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Kamali Hospital, Alborz University of Medical Sciences, Karaj, Iran
2Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2023; 10: 144-150
DOI: 10.34172/cjmb.2023.24
Viewed : 929 times
Downloaded : 608 times.

Keywords : Oxidative stress, Diabetes, Treadmill exercise, Carvacrol, Testis, Sperm parameters
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Objectives: This study aimed to evaluate the effect of carvacrol and treadmill exercise on oxidative stress and testis structure in streptozotocin (STZ)-induced diabetic rats.

Materials and Methods: In this experimental study, the diabetes was induced using a single intraperitoneal (IP) injection of STZ (50 mg/kg). The rats were assigned to five groups, namely a control group, a diabetic control group, a diabetic group receiving daily carvacrol at a dose of 75 mg/kg, diabetic groups performing treadmill exercise, and a diabetic group performing daily treadmill exercise and receiving carvacrol. After covering the treatment period, all rats were anesthetized and their blood sample were taken. Then the serum levels of oxidative stress markers were measured, the testicles and epididymis were removed, and the sperm parameters were assessed.

Results: The treatment of diabetic rats with carvacrol and treadmill exercise effectively improved testis tissue damage, sperm parameters, glucose, and insulin plasma levels (P = 0.001). In diabetic rats, the level of malondialdehyde (MDA) increased while the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes decreased in the testes tissue (P = 0.001). However, when carvacrol administration (75 mg/kg) was combined with treadmill exercise, these parameters were significantly rectified (P < 0.05).

Conclusion: In sum, administering carvacrol and performing treadmill exercise were effective in improving the sperm parameters and testicular oxidative damage caused by diabetes.


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