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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2023, Vol 10, Issue 2
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Original Article
Effect of Crocin and Treadmill Exercise on Spermatogenesis and Testis Structure in Streptozotocin-Induced Diabetic Rats: An Experimental Study
Hassan Hamidi1, Asghar Tofighi1, Javad Toluei Azar1, Amir Afshin Khaki2, Mazdak Razi3
1Department of Exercise Physiology and Corrective Movement, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

CJMB 2023; 10: 098-104
DOI: 10.34172/cjmb.2023.15
Viewed : 1479 times
Downloaded : 1704 times.

Keywords : Oxidative stress, Diabetes mellitus, Treadmill exercise, Crocin, Testis, Sperm parameters
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Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, and testis structure in streptozotocin (STZ)-induced diabetic rats.

Materials and Methods: In this experimental study, 64 diabetic rats induced by a single intraperitoneal (IP) injection of STZ (50 mg/kg) were assigned to the following groups (n=8/each): healthy control group, diabetic control group, diabetic group treated daily with crocin at a dose of 50 mg/kg, and one healthy group receiving daily crocin at a dose of 50 mg/kg for 56 days. Some groups such as the controls and diabetics exercised with treadmill, as well as the healthy and diabetic groups performed daily exercise with treadmill and crocin. After crocin treatment, all rats were anesthetized, their blood samples were taken, and the serum level of insulin, glucose, and oxidative stress markers were measured. Finally, the testicles and epididymis were removed and sperm parameters were assessed.

Results: Treatment of diabetic rats with crocin along with treadmill exercise significantly replaced the testicular tissue damage, sperm parameters, glucose, and insulin plasma levels (P = 0.001). In diabetic rats, moreover, the level of malondialdehyde (MDA) was increased and the levels of superoxide dismutase (SOD) and catalase (CAT) enzymes activity were reduced in the testicular tissue (P = 0.001). Crocin administration (50 mg/kg BW) and exercise significantly improved these parameters (P < 0.05).

Conclusions: Our results confirm the antioxidant role of crocin and the positive role of treadmill exercise in improving the sperm parameters and testicular oxidative damage caused by diabetes.


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Aras Part Medical International Press Editor-in-Chief
Arash Khaki
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Zafer Akan
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