Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2023, Vol 10, Issue 2
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?


Original Article
Effect of Crocin and Treadmill Exercise on Spermatogenesis and Testis Structure in Streptozotocin-Induced Diabetic Rats: An Experimental Study
Hassan Hamidi1, Asghar Tofighi1, Javad Toluei Azar1, Amir Afshin Khaki2, Mazdak Razi3
1Department of Exercise Physiology and Corrective Movement, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

CJMB 2023; 10: 098-104
DOI: 10.34172/cjmb.2023.15
Viewed : 722 times
Downloaded : 1099 times.

Keywords : Oxidative stress, Diabetes mellitus, Treadmill exercise, Crocin, Testis, Sperm parameters
Full Text(PDF) | Related Articles
Abstract
Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, and testis structure in streptozotocin (STZ)-induced diabetic rats.

Materials and Methods: In this experimental study, 64 diabetic rats induced by a single intraperitoneal (IP) injection of STZ (50 mg/kg) were assigned to the following groups (n=8/each): healthy control group, diabetic control group, diabetic group treated daily with crocin at a dose of 50 mg/kg, and one healthy group receiving daily crocin at a dose of 50 mg/kg for 56 days. Some groups such as the controls and diabetics exercised with treadmill, as well as the healthy and diabetic groups performed daily exercise with treadmill and crocin. After crocin treatment, all rats were anesthetized, their blood samples were taken, and the serum level of insulin, glucose, and oxidative stress markers were measured. Finally, the testicles and epididymis were removed and sperm parameters were assessed.

Results: Treatment of diabetic rats with crocin along with treadmill exercise significantly replaced the testicular tissue damage, sperm parameters, glucose, and insulin plasma levels (P = 0.001). In diabetic rats, moreover, the level of malondialdehyde (MDA) was increased and the levels of superoxide dismutase (SOD) and catalase (CAT) enzymes activity were reduced in the testicular tissue (P = 0.001). Crocin administration (50 mg/kg BW) and exercise significantly improved these parameters (P < 0.05).

Conclusions: Our results confirm the antioxidant role of crocin and the positive role of treadmill exercise in improving the sperm parameters and testicular oxidative damage caused by diabetes.

 

Cite By, Google Scholar

Google Scholar

Articles by Hamidi H
Articles by Tofighi A
Articles by Toluei Azar J
Articles by Afshin Khaki A
Articles by Razi M

PubMed

Articles by Hassan Hamidi
Articles by Asghar Tofighi
Articles by Javad Toluei Azar
Articles by Amir Afshin Khaki
Articles by Mazdak Razi

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Publisher
Aras Part Medical International Press Editor-in-Chief
Arash Khaki
Deputy Editor
Zafer Akan
Published Article Statistics