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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2023, Vol 10, Issue 1
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Original Article
Ultrasonographic and Radiographic Evaluation of Zeolite/Collagen Nanocomposite Scaffolds Compared With Nanohydroxyapatite on Experimental Bone Defect Healing in Rabbit Femur
Negar Javadian1, Abbas Veshkini1, Alireza Jahandideh2, Abolfazl Akbarzadeh3, Ahmad Asghari2
1Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Surgery, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Department of Medical Nanotechnology, School of Advanced Medical Sciences, Stem Cell Research Center, Stem Cells and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2023; 10: 049-055
DOI: 10.34172/cjmb.2023.08
Viewed : 1180 times
Downloaded : 1251 times.

Keywords : Bone scaffolds, Femur bone defect, Hydroxyapatite, Radiology, Ultrasonography, Zeolite/collagen nanocomposite
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Objectives: The use of a biomaterial scaffold can improve the healing process of bone defects. Using radiologic and ultrasonographic methods, this study aimed to evaluate the effects of zeolite/collagen nanocomposite and nanohydroxyapatite (nHA) bone scaffolds on the healing process of bone defect in rabbit femur.

Materials and Methods: Twenty-eight mature male New Zealand white rabbits were classified into four equal groups (n=7 in each). In the first group, the defect was made, and the wound was closed with no treatment; in the second group, the nHA was implanted into the defect; in the third group, the nanocomposite of zeolite/collagen was implanted; and in the fourth group, the defect was filled using autograft. Radiologic (Sedecal Veterinary X-Ray System, Model No. A6544-2) and ultrasonographic (Mindray Z5 Veterinary Ultrasound Scanner) examinations were done on days 0, 15, 30, 45, and 60 postoperatively.

Results: There were no healing effects on days 0 and 7 in any of the studied groups in the radiologic examination. The highest and lowest healing effects were related to treatment with zeolite/collagen nanocomposite and control group on day 60 after operation, respectively. There was no angiogenesis on day 0 in any group in the ultrasonographic examination. The highest and lowest levels of angiogenesis were related to rabbits treated with zeolite/collagen nanocomposite and the control group on day 30 after operation, respectively. Also, bone filling and angiogenesis in rabbits treated with zeolite/collagen nanocomposite were higher than other groups.

Conclusions: Zeolite/collagen nanocomposite scaffolds bear a crucial capability in the reconstruction of bone defects and can be used in bone fractures.


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