|Comparison of Clinico-Pathological Features Between Epithelial Ovarian Cancer Patients With and Without Endometriosis: A Cross-Sectional Study|
|Mehri Jafari Shobeiri1, Navideh Hajagaei Saeidi1, Heidar Ali Esmaeili2, Ali Dastranj Tabrizi2, Yasmin Pouraliakbar1, Parvin Mostafa-Gharabaghi1, Manizheh Sayyah-Melli1, Maryam Vaezi1, Vahideh Rahmani1, Sajjad Pourasghari1|
|1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Keywords : Endometriosis, Ovarian epithelial cancer, Carcinoma
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Objectives: Women with endometriosis have a high risk of developing ovarian carcinoma that may occur due to endometriosis lesions. There is few research have so far focused on the clinical factors in patients with endometriosis-associated ovarian cancer (EAOC). Accordingly, this study aimed at comparing the demographic and obstetric characteristics between ovarian cancer with and without endometriosis
Materials and Methods: This cross-sectional study was conducted on 20 EAOC patients and 140 non-EAOC individuals who had gone under surgery from 2011-17 at Al-Zahra hospital. Clinico-pathological characteristics of the two groups including first group only had malignant epithelial ovarian tumor (non-EAOC) and second group had both malignant epithelial ovarian tumor and endometriosis (EAOC). P value less than 0.05 was considered statistically significant.
Results: EAOC cases were significantly younger (P = 0.002) and had lower number of pregnancy (P = 0.002), parity (P = 0.004), and term pregnancy (P = 0.005) than non-EAOC patients. A large proportion of EAOC cases had clear cell and endometrioid histopathology in comparison to non-EAOC individuals (P < 0.001) and most of the tumors in these cases were unilateral (P = 0.01).
Conclusions: We found that age, parity, gravidity, and term pregnancy as well as laterality and histopathologic type of epithelial ovarian cancers vary in EAOC and non-EAOC individuals. Further research is required to identify these differences.
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