The Comparative Effects of Platelet-Rich Plasma and Polycaprolactone-Hydroxyapatite Zeolite Nanocomposites on Wound Healing After Tooth Extraction

Alireza Sagart; Alireza Jahandideh; Ahmad Asghari; Abolfazl Akbarzadeh; Pejman Mortazavi

doi:10.34172/cjmb.2023.33

E-ISSN : 2148-9696

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Original Article
The Comparative Effects of Platelet-Rich Plasma and Polycaprolactone-Hydroxyapatite Zeolite Nanocomposites on Wound Healing After Tooth Extraction
Alireza Sagart¹, Alireza Jahandideh¹, Ahmad Asghari¹, Abolfazl Akbarzadeh², Pejman Mortazavi³
¹Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran ²Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ³Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
CJMB 2024; 11: 183-189 DOI: 10.34172/cjmb.2023.33 Viewed : 1437 times Downloaded : 2070 times. Keywords : Nanocomposite, Polycaprolactone-hydroxyapatite-zeolite, Tooth extract, Cavity, Wound healing
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Abstract

Objectives: Post tooth extraction type of wound healing is a convoluted process that helps wounds reform. This study aims to evaluate the impact of polycaprolactone-hydroxyapatite zeolite nanocomposites on the healing processes of mucosa overlying post-extraction alveolus. Materials and Methods: Fifteen healthy cats with premolar lower tooth involvement were selected for tooth extraction. The biopsy sampling from the mucosa of the alveolus was performed on the 10th postoperative day. The cats were grouped as control, platelet-rich plasma (PRP), and nano polycaprolactone-hydroxyapatite zeolite. Results: The histopathologic analysis showed that contrary to controls and PRP, the nano group had a lower presence of inflammatory cells, a complete irregular thick epithelium, more granulation tissue, and more fibrosis. So, nano polycaprolactone-hydroxyapatite zeolite accelerated the healing process after tooth extraction. Conclusion: Nanocomposite containing nano zeolite can improve wound healing after tooth extraction.