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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2022, Vol 9, Issue 4
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Original Article
Evaluating Walnut-Fig Syrup as an Innovative Herbal Medicine for Functional Constipation in the Elderly: A Randomized Controlled Clinical Trial
Saeed Joudikhajeh1,2, Bita Sepehri3, Robab Mehdizadeh Esfanjani4, Hossein Rezaeizadeh5, Yunes Ranjbar6, Mostafa Araj-Khodaei7
1Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran,
6Baharan Private Clinic Research Team, Tabriz, Iran
7Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2022; 9: 195-201
DOI: 10.34172/cjmb.2022.32
Viewed : 931 times
Downloaded : 1013 times.

Keywords : Walnut, Fig, Aging, Functional constipation, Traditional medicine
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Objectives: Functional constipation (FC), or chronic idiopathic constipation, is one of the most common chronic disorders with no specific cause. Although FC is not associated with the progress of severe disease or additional mortality, it significantly decreases the patients" quality of life. While several medications are available to treat constipation, there is no adequate treatment response in most cases. Herbal remedies are one of the most widely used options for FC.

Materials and Methods: In this double-blind controlled trial, all patients, researchers, and analysts were unaware of the ingredients contained in the drugs, as well as the assigned groups. We recruited a total of 90 elderly patients diagnosed with FC according to the Rome IV diagnostic criteria for irritable bowel syndrome (IBS). Patients were divided into two equal groups (n=45 in each) receiving fig-walnut syrup and lactulose syrup. Then, CBC-FBS-TSH-CR-NA-K-CA tests were taken from all patients, and the developed syrups (walnut-fig or lactulose) were prescribed to patients (15 cc half an hour before bedtime).

Results: While 43 (95.6%) patients responded to treatment in the intervention group, 41 (91.1%) patients responded to treatment in the conventional treatment group. There was no statistically significant difference between the two groups in terms of response to treatment (P = 0.677).

Conclusions: The results showed that the oral syrups developed in this study improved FC in the elderly and had no side effects.


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