Evaluating Walnut-Fig Syrup as an Innovative Herbal Medicine for Functional Constipation in the Elderly: A Randomized Controlled Clinical Trial

Saeed Joudikhajeh; Bita Sepehri; Robab Mehdizadeh Esfanjani; Hossein Rezaeizadeh; Yunes Ranjbar; Mostafa Araj-Khodaei

doi:10.34172/cjmb.2022.32

E-ISSN : 2148-9696

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Original Article
Evaluating Walnut-Fig Syrup as an Innovative Herbal Medicine for Functional Constipation in the Elderly: A Randomized Controlled Clinical Trial
Saeed Joudikhajeh^1,2, Bita Sepehri³, Robab Mehdizadeh Esfanjani⁴, Hossein Rezaeizadeh⁵, Yunes Ranjbar⁶, Mostafa Araj-Khodaei⁷
¹Student Research Committee, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran ²Department of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ³Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ⁴Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran ⁵Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, ⁶Baharan Private Clinic Research Team, Tabriz, Iran ⁷Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
CJMB 2022; 9: 195-201 DOI: 10.34172/cjmb.2022.32 Viewed : 1012 times Downloaded : 1116 times. Keywords : Walnut, Fig, Aging, Functional constipation, Traditional medicine
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Abstract

Objectives: Functional constipation (FC), or chronic idiopathic constipation, is one of the most common chronic disorders with no specific cause. Although FC is not associated with the progress of severe disease or additional mortality, it significantly decreases the patients" quality of life. While several medications are available to treat constipation, there is no adequate treatment response in most cases. Herbal remedies are one of the most widely used options for FC. Materials and Methods: In this double-blind controlled trial, all patients, researchers, and analysts were unaware of the ingredients contained in the drugs, as well as the assigned groups. We recruited a total of 90 elderly patients diagnosed with FC according to the Rome IV diagnostic criteria for irritable bowel syndrome (IBS). Patients were divided into two equal groups (n=45 in each) receiving fig-walnut syrup and lactulose syrup. Then, CBC-FBS-TSH-CR-NA-K-CA tests were taken from all patients, and the developed syrups (walnut-fig or lactulose) were prescribed to patients (15 cc half an hour before bedtime). Results: While 43 (95.6%) patients responded to treatment in the intervention group, 41 (91.1%) patients responded to treatment in the conventional treatment group. There was no statistically significant difference between the two groups in terms of response to treatment (P = 0.677). Conclusions: The results showed that the oral syrups developed in this study improved FC in the elderly and had no side effects.