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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2022, Vol 9, Issue 4
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Original Article
Clinico-pathological Features and Survival Time of Papillary Thyroid Carcinoma in Patients With and Without Hashimoto"s Thyroiditis: A Cross-sectional Study
Mansour Moghimi1, Fateme Sadat Shamsadini Ezabadi2, Seyed Mohammadreza Mortazavi Zadeh3, Saead Hossein Khalilzade3
1Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Faculty of Medicine, Islamic Azad University of Yazd, Yazd, Iran
3Department of Hematology-Oncology, Islamic Azad University of Yazd, Yazd, Iran
4Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


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Keywords : Cancer, Papillary thyroid carcinoma, Hashimoto"s thyroiditis, Recurrence
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Abstract

Objectives: Researchers have reported different results regarding the association between Hashimoto’s disease and papillary thyroid carcinoma (PTC). Some believe that the coexistence of these diseases can lead to fewer tumor invasion and recurrence rates. This study evaluated the clinico-pathological features and survival time of PTC in patients with and without Hashimoto’s thyroiditis.

Materials and Methods: In this cross-sectional study, medical records of 251 participants who underwent total or subtotal thyroidectomy due to PTC from 2012 to 2019 were reviewed. The clinico-pathological features of participants, such as age, gender, tumor stage, tumor size, lymph node involvement, metastasis, capsular invasion, single or multi-focal tumor status, and survival time were recorded from their medical records and pathology report and compared in two groups with and without Hashimoto’s thyroiditis.

Results: From 251 participants, 92 (36.6%) had Hashimoto’s thyroiditis, whereas 159 (63.4%) did not show any signs of this disease. Fifteen participants in the Hashimoto group and 46 in the non-Hashimoto group had a recurrence. Although there were no significant differences between the two groups in the term of recurrence rate (P = 0.08), the mean survival time was significantly difference between the two groups (69.03 and 58.78, respectively; P = 0.038)

Conclusions: Results of the study revealed that Hashimoto’s thyroiditis could increase the survival time of patients with PTC.

 

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Aras Part Medical International Press Editor-in-Chief
Arash Khaki
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Zafer Akan
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