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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2022, Vol 9, Issue 3
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Original Article
Comparison of the Effects of Injectable Enoxaparin With Oral Rivaroxaban in Deep Vein Thrombotic Prophylaxis in Patients With Femoral Peritrochanteric Fracture: A Randomized Clinical Trial
Mosayeb Hoseinzadeh1, Mohammad Reza Bazavar1
1Department of Orthopedics Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2022; 9: 132-137
DOI: 10.34172/cjmb.2022.23
Viewed : 120 times
Downloaded : 79 times.

Keywords : Rivaroxaban, Enoxaparin, Deep vein thrombosis, Peritrochanteric femur fracture
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Abstract
Objectives: The prevalence of deep vein thrombosis (DVT) following orthopedic major surgery, such as peritrochanteric femoral fracture, is high. Also, there is a lack of accurate information about the results of using rivaroxaban in Iran. This study aimed to compare the effects of injectable enoxaparin with oral rivaroxaban in DVT prophylaxis in patients with femoral peritrochanteric fracture.

Materials and Methods: This randomized single-blind clinical trial included 88 patients with femoral peritrochanteric fracture in Shohada Hospital of Tabriz, Iran from January 2019 to December 2019. The participants were randomly allocated into two equal groups (n=44 each) receiving enoxaparin (40 mg subcutaneously once daily for 28 days) and rivaroxaban (10 mg orally once daily for 28 days). Using independent t test in SPSS version 20, the results of clinical examinations and ultrasonography for the diagnosis of DVT at the end of intervention were compared between the two groups. A P value less than 0.05 was considered as statistically significant.

Results: No significant differences were observed in laboratory results and DVT-related symptoms between the two groups, as well as before and after the intervention (intragroup). Also, the prevalence of DVT at the end of the study was zero.

Conclusions: According to our results, there was no difference in the prevalence of DVT and short-term (one-month) complications between the two groups receiving rivaroxaban and enoxaparin after the peritrochanteric femur fracture.

 

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