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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2022, Vol 9, Issue 4
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Original Article
Comparing the Effectiveness of Metoclopramide, Low Dose of Propofol, Ondansetron, and Magnesium Sulfate on Propofol Injection Pain: A Double-Blind Clinical Trial
Gelareh Biazar1, Farnoush Farzi1, Samaneh Ghazanfar Tehran1, Reyhaneh Shahrokhi Rad1, Mohammad Reza Habibi1, Mahsa Khosousi Sani2, Amer Chohdary3, Alireza Yaghoobi3, Ladan Mirmansouri4
1Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
2Reproductive Health Research Center, Department of Obstetrics and Gynecology, Al-Zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
3Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
4Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran

CJMB 2022; 9: 202-206
DOI: 10.34172/cjmb.2022.33
Viewed : 1540 times
Downloaded : 1811 times.

Keywords : Propofol, Injection, Pain, Metoclopramide, Ondansetron, Magnesium sulfate Metoclopramide, Ondansetron, Magnesium sulfate
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Objectives: Despite a variety of strategies, propofol injection pain (PIP) is still one of the most distressing adverse effects of the drug. This study aimed to compare the effectiveness of metoclopramide, low dose of propofol, magnesium sulfate, and ondansetron in the prevention of PIP.

Materials and Methods: This double-blind clinical trial was conducted at Al-Zahra hospital an academic and referral center affiliated with Guilan University of Medical Sciences, Rasht, Iran. A total of 120 eligible women candidates for elective gynecologic surgeries were divided into four equal groups of magnesium sulfate (30 mg/kg), ondansetron (4 mg), metoclopramide (10 mg), and propofol (15 mg). The primary outcome of this study was to decrease the pain severity of propofol injection.

Results: The participants" demographic characteristics, including age, American Society of Anesthesiologists classification, and body mass index, had no significant differences between the four groups. A significant decrease in heart rate and mean arterial pressure were observed in four groups; however, the difference was insignificant. The mean pain intensity in the magnesium sulfate group was 1.57 ± 0.9, ondansetron 1.37 ± 0.89, metoclopramide 0.95 ± 0.93, and in propofol group was 1.25 ± 1.1 (P=0.036).

Conclusions: Metoclopramide could appropriately alleviate PIP. Considering some additional advantages, including antiemetic properties, preventing esophageal reflux, and less risk of postoperative ileus, this drug could be a safe and acceptable choice.


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Articles by Biazar G
Articles by Farzi F
Articles by Ghazanfar Tehran S
Articles by Shahrokhi Rad R
Articles by Reza Habibi M
Articles by Khosousi Sani M
Articles by Chohdary A
Articles by Yaghoobi A
Articles by Mirmansouri L


Articles by Gelareh Biazar
Articles by Farnoush Farzi
Articles by Amer Chohdary
Articles by Alireza Yaghoobi
Articles by Ladan Mirmansouri

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