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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2021, Vol 8, Issue 4
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Original Article
Effects of Hydroalcoholic Extracts of Cloves (Syzygium aromaticum) on the Serum Biomarkers, Antioxidant Status, and Histopathological Changes of Kidneys in Diabetic Rats
Seyd-Hosein Abtahi-Eivari1, Majid Shokoohi2,3, Mohammad Ghorbani1, Monireh Halimi3, Hossein Hajizadeh4, Tala Pourlak3, Javad Bahrami5, Zohreh Ghoreishi6
1Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Department of Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
5Department of Environmental Health Engineering, Faculty of Health, Zanjan University of Medical Sciences, Zanjan, Iran
6Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2021; 8: 269-275

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Keywords : Cloves, Diabetes, Lipid profile, Antioxidant status, Kidney damages
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Objectives: The purpose of this study was to assess the possible impact of hydroalcoholic extracts of cloves (Syzygium aromaticum) on glucose status, lipid profile, and histopathological changes in the kidneys of diabetic rats.

Materials and Methods: Thirty-two rats (male) were distributed into 4 groups (n=8), including one group as healthy control and three diabetic groups. Streptozotocin was used for inducing diabetes (50 mg/kg). Diabetic rats were grouped into a control group (DC), diabetic treated with 4 mg/kg hydroalcoholic extract of S. aromaticum (DSA), and the DG group receiving 5 mg/kg glibenclamide. After the treatment period, the blood samples of the rats were frozen in -70°C for measuring glycemic indices, insulin, lipid profile, some oxidative stress markers, and enzymes with antioxidant properties. Finally, the kidney was removed for the histological study.

Results: Control, DSA, and DG groups had significantly lower levels of fasting blood sugar compared to the DC group (P<0.05) while the levels of insulin were significantly lower in the DC, DSA, and DG groups compared to the control group (P<0.05). The serum levels of urea and creatinine statistically reduced in all groups other than the DC group (P<0.05). Conversely, the levels of superoxide dismutase, glutathione peroxidase, and significantly increased in the DSA and DG as compared to the DC group although the serum levels of malondialdehyde statistically decreased in the therapeutic groups. S. aromaticum showed antioxidant properties and protected the kidneys of the experimented rats from renal damages, resulting from diabetes.

Conclusions: This study demonstrated that S. aromaticum may have beneficial effects in diabetes through improving glycemic control and lipid profile and preventing diabetes-induced kidney damages.


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Articles by Abtahi-eivari S
Articles by Shokoohi M
Articles by Ghorbani M
Articles by Halimi M
Articles by Hajizadeh H
Articles by Pourlak T
Articles by Bahrami J
Articles by Ghoreishi Z


Articles by Majid Shokoohi
Articles by Mohammad Ghorbani
Articles by Monireh Halimi
Articles by Hossein Hajizadeh
Articles by Tala Pourlak
Articles by Javad Bahrami
Articles by Zohreh Ghoreishi

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