Determination of Lead and Arsenic Concentrations in the Serum and its Effect on Sperm Parameters and Sperm Quality in Patients Referred to Omid Persian Gulf Infertility Center of Bushehr

Hossein Khoramdel; Parviz Farzadinia; Mehrdad Shariati; Mokhtar Mokhtari; Afshar Bargahi

E-ISSN : 2148-9696

Crescent Journal of
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Jul 2021, Vol 8, Issue 3

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Original Article
Determination of Lead and Arsenic Concentrations in the Serum and its Effect on Sperm Parameters and Sperm Quality in Patients Referred to Omid Persian Gulf Infertility Center of Bushehr
Hossein Khoramdel¹, Parviz Farzadinia², Mehrdad Shariati¹, Mokhtar Mokhtari¹, Afshar Bargahi³
¹Department of Biology, Kazerun Branch, Islamic Azad University Kazerun, Iran ²Department of Biology and Anatomical Sciences, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran ³The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
CJMB 2021; 8: 168-173 Viewed : 2059 times Downloaded : 1538 times. Keywords : Lead, Arsenic, Male infertility, Chromatin condensation, Protamine, Seminal quality
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Abstract

Objectives: Arsenic (As) and lead (Pb) are widespread in the environment and human exposure to these elements has a broad range of toxic effects. However, the knowledge of possible mechanisms of As and Pb in male reproductive toxicity is generally negligible. Materials and Methods: The aim of this study was to investigate the possibility of the presence of Pb or As in the serum of infertile men and the relation between them and DNA damage in the sperm by using the enzyme-linked immunosorbent assay, atomic adsorption, and chromatin attaining. Results: These results showed that there is a significant correlation between high levels of Pb and As in the serum and semen quality in infertile men. Finally, the results of chromatin condensation (CMA3) staining demonstrated a high level of damage in the sperms of infertile men. Conclusions: It was hypothesized that Pb and As have interaction effects on histone to protamine replacement and prevent the chromatin condensation, resulting in a reduction in male fertility.