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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2020, Vol 7, Issue 4
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Short Communication
Frequency of Sperm DNA Fragmentation Index in Infertile Couples With Male Factor Infertility
Tayybeh Khamar1, Mehrnaz Narooie-Nejad2, Leila Kordi1, Farahnaz Farzaneh3
1Student Research Committee, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
2Genetic Department, Zahedan University of Medical Sciences, Zahedan, Iran
3Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Assistant Professor of Zahedan University of Medical Sciences, Zahedan, Iran

CJMB 2020; 7: 560–563

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Keywords : Sperm DNA fragmentation index, DFI, Infertility, Semen analysis, Male factor
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Objectives: Today, sperm DNA fragmentation is considered as one of the causes of male infertility. The aim of this study was to investigate the frequency of sperm DNA fragmentation index (DFI) in male factor infertility.

Materials and Methods: This cross-sectional study was performed on 100 infertile men referred to Infertility Clinic of Zahedan (Iran) in 2017. Patients were selected using simple random sampling. All sperm parameters were analyzed for the patients. The sperm DFI was determined using Halosperm test and patients were divided into two groups with low sperm DFI (≤30%) and high sperm DFI (>30%).

Results: The mean age and sperm DFI of patients were 34.29 ± 4.18 years and %34.69 ± 19.13, respectively. From these patients, 55% had low DFI (less than 30%) and 45% had a high DFI (greater than 30%). The normal sperm morphology in the group with sperm DFI greater than 30% significantly was lower than that in the group with sperm DFI less than or equal to 30%.

Conclusions: The findings of this study indicated an inverse relationship between sperm DFI and sperm morphology. Conducting DFI tests to examine the anomalies and sperm DNA damage in infertile men is highly recommended.


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