Materials and Methods: This study was a clinical trial. Fifty-one brain injury traumatized patients (including 18 patients in the familiar voice group, 18 patients in recitation of prayer group and 15 patients in the control group) were divided into experimental and control groups. The first group was tested for 14 days, twice a day and received family voices through headphones at noon and evening prayer time. The second group was tested under similar condition and received the Azan sound. Immediately hemodynamic changes before and after each intervention were recorded. The average duration of voice in the two groups was 4 minutes. The control group received no intervention and hemodynamic status was recorded twice a day at noon and evening prayer time. The data was analyzed by using SPSS and chi-square test, ANOVA and repeated measures.

Results: The age range was 14 to 68 years. Azan group had the highest average age (41.2 ± 18.5 years). The highest initial consciousness level was in the control group (7.6 ± 3.5). Azan group before the intervention had the longest duration of coma (8 ± 4.7 days).The experimental group showed a significant correlation with the number of days and in some variables to the baseline, but did not show the uniformity trend in hemodynamics variables. Followed by post hoc test there was a significant increase in levels of hemodynamic parameters’ (systolic pressure, diastolic pressure, mean arterial pressure and breathing), especially after the Azan sound.

Conclusion: Auditory stimulation by family voices and recitation of prayers or Azan sound cannot increase or decrease the uniform trend in hemodynamics variables in comatose patients.