|Serum Level of Resistin in Asthmatic Children
|Lida Saboktakin1, Nemat Bilan1, Sadegh Poor Ebrahim2
|1Pediatric Health Research Center, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran
2Danesh Laboratory, Tabriz, Iran
CJMB 2019; 6: 535–539
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Keywords : Asthma, Resistin, Children, Obesity, Environmental factors
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Objectives:Asthma and intermittent asthma attacks impose a heavy mental and fnancial burden on families and serum level of resistin inﬂuences the incidence of childhood asthma and response to drug therapies. The purpose of this paper was to assess the serum level of resistin in asthmatic children in the division of pulmonary and respiratory diseases at Tabriz Children’s hospital.
Materials and Methods: This study was conducted on 50 subjects in the control group and 50 subjects in the case group (asthmatic and healthy prepubertal children under 12 years old with a normal (BMI) (5-84th percentile); asthmatic and healthy overweight prepubertal children under 12 years old (85-94th percentile); and obese prepubertal children under 12 years old (BMI ≥95) without any other illnesses. The control group was matched to the case group in terms of age and sex and did not have inﬂammatory, acute and chronic infectious diseases or a history of medication consumption. Venous blood samples were collected from the subjects after 8 hours of fasting. Serum levels of resistin were measured using Elisa.
Results: The level of resistin increased with asthma severity. Increased weight and BMI also led to a signifcant increase in the severity of asthma. The serum levels of resistin were signifcantly higher in the subjects of the control group who did not receive drug therapy. Response to drug therapy was signifcantly poorer in tall, heavier and high-BMI subjects than in other groups. The number of cases with severe persistent asthma was greater in formula-fed and breastmilk/formula-fed babies. History of allergy or asthma in frst-degree relatives was signifcantly higher in the case group than in the control group (P=0.001). Indoor smoking had a signifcant effect on the type of asthma (P=0.001). The history of non-asthmatic allergy
Conclusions: Obesity and overweight are among the inﬂuential factors in the severity of asthma. The amount of resistin is signifcantly higher in children with severe persistent asthma and uncontrolled asthma than in healthy children. However, the results showed that smoking may also increase serum resistin in at-risk individuals.
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