Comparing the Efficacy of Cumin Sofouf With Mebeverine on Irritable Bowel Syndrome Severity and Quality of Life: A Double-blind Randomized Clinical Trial

Khadijeh Hatami; Amir-Hooman Kazemi-Motlagh; Hossein Ajdarkosh; Arman Zargaran; Mehrdad Karimi; Ahmad Reza Shamshiri; Mohammad Reza Ghadir

E-ISSN : 2148-9696

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Apr 2020, Vol 7, Issue 2

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Original Article
Comparing the Efficacy of Cumin Sofouf With Mebeverine on Irritable Bowel Syndrome Severity and Quality of Life: A Double-blind Randomized Clinical Trial
Khadijeh Hatami¹, Amir-Hooman Kazemi-Motlagh¹, Hossein Ajdarkosh², Arman Zargaran³, Mehrdad Karimi¹, Ahmad Reza Shamshiri⁴, Mohammad Reza Ghadir⁵
¹Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran ²Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran ³Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran ⁴Community Oral Health Department, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran ⁵Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran
CJMB 2020; 7: 186-194 Viewed : 3915 times Downloaded : 12873 times. Keywords : Herbal medicine, Irritable bowel syndrome, IBS-severity score, IBS-quality of life
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Abstract

Objectives: The treatment of irritable bowel syndrome (IBS) is not curative and is based on patient symptoms. Some herbal medicines have significant effects on IBS symptoms. The present study aimed to assess the efficacy of a recommended drug from Persian medicine (Cumin Sofouf) on the score of IBS symptom severity and the quality of life as a clinical trial compared with mebeverine, which is a commonly used antispasmodic drug for this disorder. Materials and Methods: In this double-blind randomized clinical trial, eligible patients were allocated to two groups. One group received 200 mg sustain release mebeverine capsule plus placebo sofouf and another group received the sachets of cumin sofouf plus placebo capsule. Cumin sofouf contains the seed powder of Bunium persicum, Trachyspermum ammi, Foeniculum vulgare, and Pimpinella anisum. Patients were requested to fill IBS-symptom severity score (IBS-SSS) and IBS-quality of life (IBS-QoL) questionnaires at the base and after 4 weeks of treatment. Results: Data of 40 patients in each group entered the analysis step. Based on the results, IBS-SSS decreased by 120.13 (SD = 66.04) and 70.75 (SD = 50.75) point after 4 weeks in cumin sofouf and mebeverine groups, respectively. in addition, cumin sofouf was statistically more effective than mebeverine, which was also about IBS-SSS substructures. Further, the IBS-QOL score decreased by 17.40 (SD = 13.66) and 8.55 (SD = 6.88) point in sofouf and mebeverine groups, respectively. Finally, cumin sofouf was significantly more effective than mebeverine. Conclusions: According to the results, cumin sofouf could be recommended as a supplementary remedy for IBS patients.