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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2016, Vol 3, Issue 2
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Original Article
Magnesium Sulfate Improves Sperm Characteristics Against Varicocele in Rat
Ahmad Asghari1, Ghasem Akbari2, Geghani Galustanian3
1Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Theriogenology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Graduate Student, Science and Research Branch, Islamic Azad University, Tehran, Iran

CJMB 2016; 3: 055-059

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Keywords : Magnesium sulfate, Rat, Varicocele
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Objective: The main purpose of this study was to determine the effect of magnesium sulfate on sperm characteristics in unilateral varicocele-induced male Wistar rats.

Materials and Methods: Sixty male Wistar rats were randomly divided into 6 experimental groups. The control group (1) received no medications and surgery. The Sham group (2) had not received any medications; abdominal cavity was opened but no varicocele was induced. Varicocele group (3): abdominal cavity was opened, varicocele-induced and no medications were applied. In group 4 abdominal cavity was opened, varicocele-induced and animal received magnesium sulfate (25 mg/kg) for 6 weeks. The groups 5 and 6 were similar to group 4, except animals received 50 and 100 mg/kg of magnesium sulfate, respectively. At the end of the weeks 3 and 6, the abdomen was opened, semen samples were collected from the Caudal epididymis to determine epididymis weight, sperm mortality, mobility and sperm count.

Results: According to the results, experimental unilateral varicocele significantly diminished sperm mortality, mobility and sperm count compared to control and sham group (P < 0.05). Administration of magnesium sulfate as a medication dose dependently (25, 50 and 100 mg/kg) decreased sperm mortality and increased mobility and sperm count in experimental varicocele in rat compared to varicocele group at weeks 3 and 6 (P < 0.05).

Conclusion: According to the results, it seems, magnesium sulfate might improve sperm characteristics during varicocele.


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