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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2019, Vol 6, Issue 3
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Original Article
Protective Effect of Fumaria parviflora Extract on Oxidative Stress and Testis Tissue Damage in Diabetic Rats
Majid Shokoohi1, Mohammad Sadegh Gholami Farashah1, Arash Khaki1, Amir Afshin Khaki1, Elaheh Ouladsahebmadarek1, Reza Aref Nezhad3
1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

CJMB 2019; 6: 355-360

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Keywords : Diabetes, Fumaria parviflora, Testis, Sperm parameters, Oxidative stress
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Objectives: In this experimental research, a rat model was used to investigate the protective effect of Fumaria parviflora on oxidative stress and testis tissue damage in diabetic rats.

Materials and Methods: To this end, a total of 28 male Wistar rats were utilized and randomly divided into 4 groups including control group (G1), diabetic control group (G2, DC), diabetic treated with F. parviflora extract (G3), and healthy group (G4) that received F. parviflora extract. In addition, the therapy lasted for 56 days. Then, the blood levels of some markers of oxidative stress and antioxidant enzymes, as well as sperm parameters such as concentration, motility, and morphology were assayed based on the aim of the study.

Results: The histological examination showed a negative change in the DC group, and they were included in the treated groups. The plasma levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly reduced in the DC group while the malondialdehyde (MDA) level enhanced the duration of diabetes. As regards the sperm parameters, the results demonstrated a significant reduction in the DC group whereas treatment with FP extract led to an increase in the quality of sperm.

Conclusions: Based on the results of the present research, the F. parviflora extract has a positive role in protecting the testis tissue and sperm quality against oxidative stress in diabetic rats.


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