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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2016, Vol 3, Issue 3
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Original Article
Histological Study of the Placenta in Neonates With Intrauterine Growth Retardation
Hossein Mohammad Alizadeh Fard1, Fatemehe Afshari1, Zahra Ghatre Samani2
1Department of Histopathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2Department of Gynecology, Tabriz Branch, Islamic Azad University, Tabriz, Iran

CJMB 2016; 3: 107-110

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Keywords : Fetal growth retardation, Fibrosis, Gestational age, Placenta
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Objective: Placenta is the maternofetal contact zone, provided by normal membranes and endometrium, for which the intrauterine fetal life depends on. Regarding the importance of placenta in embryonic period, this study aims at investigating the histopathological changes of placenta in newborns with intrauterine growth retardation (IUGR).

Materials and Methods: This study was performed on two groups (control and experimental) of pregnant women with IUGR fetus in the Histological Department of Medical School of Azad University, Tabriz. In the experimental group, 30 samples of IUGR placentas were examined. The samples were first fixed in formalin, embedded in paraffinized mold, and cut into 5 μm sections. After that, the samples were prepared for staining with Hematoxylin and Eosin (H&E), trichrome, and PAS techniques.

Results: Findings showed the increase of syncytial knots and fibrinoid, the presence of villous fibrosis, and decrease of glycogen deposit in the experimental group. In addition, statistical investigations suggested that placental and fetal weights in the experimental group were significantly lower than control group (P < 0.05).

Conclusion: The results obtained from this study showed that fetal placental and birth weights were lower than control group. Pathological results showed increase of syncytial knots and fibrinoid in the experimental group in comparison to control group.


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