Materials and Methods: This is a comparative descriptive study in which the proposed model for the national information research system in the domain of medical and biomedical was initially prepared basing on comparison then the applicability of the model to meet users’ needs was presented for final evaluation in the form of a survey to 40 users which were selected based on convenience sampling. A questionnaire was the tool used for gathering the data. The reliability and validity of the questionnaire was approved by a Cronbach alpha reliability of 94%. Descriptive statistic was used for data analysis.

Results: Results of the survey conducted on users indicated that all of the participants with the majority of items and categories presented in a designated five axes had a unanimous consensus and no item has been opposed. Also, cases such as the presence of educational system, researchers’ evaluation system, automatic identification of research priorities and the process of integrating research outputs into industry were taken into consideration.

Conclusion: For the success of the system, all stakeholders involved in medical and biomedical research must coordinate in determining priorities, creating health research networking and in strengthening the overall capacity of the network and in collecting the baseline data. Assessment of tools and the stages of research implementation with corporate and national supervision, must comply with international scientific and ethical standards.