Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2016, Vol 3, Issue 3
Advanced Search
How do you find the scientific quality of the published articles on our web site?
Original Article
The Relation of Lumbar Disc Herniation With Increased Lipid Hydroperoxide, Paraoxonase 1 and Total Oxidative Status
Hamza Karabag1, Sezen Hatice2
1Assistant Professor, Harran University Faculty of Medicine, Department of Neurosurgery, Sanliurfa, Turkey
2Assistant Professor, Harran University Faculty of Medicine, Department of Clinical Biochemistry, Sanliurfa, Turkey

CJMB 2016; 3: 086-090

Viewed : 1462 times
Downloaded : 2529 times.

Keywords : Lumbar disc herniation, lipid hydro-peroxide, paraoxonase 1
Full Text(PDF) | Related Articles
Objective: Lumbar disc herniation (LDH) is well known low back disorder. Beside a lot of reason, the chronic inflammation is stated to have a role in the importance of LDH. As known, there is a complex connection between inflammation and oxidative stress. The relationship between LDH and the levels of lipid hydroperoxide (LOOH), total oxidative status (TOS), paraoxonase 1 (PON1) and total antioxidative status (TAS) has not been studied until now. The purpose of this study was to evaluate the levels of oxidative markers, such as LOOH, TOS, PON1 and TAS in patients with preoperative stage of disc herniation.

Materials and Methods: Fifty consecutive patients (8 patients were excluded; n = 42) with LDH and 50 healthy controls were subjected in this prospective study. Serum PON1, LOOH, TAS and TOS levels were determined.

Results: Serum PON-1 level was found to be significantly lower (P = 0.008), serum TAS and LOOH levels were measured as significantly higher (both P < 0.001) in the LDH group than in the control group. Positive significant correlations were detected between LOOH and TAS, TOS, and oxidative stress index (OSI); then again between OSI and low-density lipoprotein cholesterol (LDL-C).

Conclusion: The inflammatory-oxidant environment decreased PON1 and increased LOOH- may be the cause or reason of disc herniation. This result suggests that LDH may be related with atherosclerosis.


Cite By, Google Scholar

Google Scholar

Articles by Karabag H
Articles by Hatice S


Articles by Hamza Karabag
Articles by Sezen Hatice

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Aras Part Medical International Press Editor-in-Chief
Arash Khaki
Deputy Editor
Zafer Akan
Published Article Statistics