Determining the Efficacy of Some Hospital Disinfectants Against Methicillin-Resistant Staphylococci Isolated From Different Wards of an Educational Hospital

Seyed Ali Sajjadi; Jalal Mardaneh; Alireza Mohammadzadeh; Roghye Hojjatpanah; Hossein Nezami; Mostafa Amiri; Mehdi Ghasemi

E-ISSN : 2148-9696

Crescent Journal of
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Jul 2020, Vol 7, Issue 3

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Original Article
Determining the Efficacy of Some Hospital Disinfectants Against Methicillin-Resistant Staphylococci Isolated From Different Wards of an Educational Hospital
Seyed Ali Sajjadi¹, Jalal Mardaneh², Alireza Mohammadzadeh², Roghye Hojjatpanah³, Hossein Nezami⁴, Mostafa Amiri⁵, Mehdi Ghasemi¹
¹Department of Environmental Health Engineering and Social Determinants of Health Research Centre, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran ²Department of Microbiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran ³Student’s Research Committee, Department of Environmental Health Engineering, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran ⁴Department of Basic Sciences, Faculty of Medicine, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran ⁵Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
CJMB 2020; 7: 355-361 Viewed : 3774 times Downloaded : 2312 times. Keywords : MRAS, Staphylococcus epidermidis, Staphylococcus saprophyticus, Disinfectants, Nosocomial infections
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Abstract

Objectives: Methicillin-resistant staphylococci are important causes of nosocomial infections. Due to the presence of these bacteria in hospitals as a significant challenge in hospital infection control, the identification of effective disinfectants against methicillin-resistant staphylococci is necessary. This study was designed to evaluate the effectiveness of common hospital disinfectants against methicillin-resistant staphylococci. Materials and Methods: In this cross-sectional study, the effectiveness of 4 surface disinfectant cleaners (Deconex 50 AF, Microzed GP-H, Peranacid M1 and Surfocept quick) against methicillin-resistant staphylococci (10 Staphylococcus aureus, 10 Staphylococcus saprophyticus, and 55 Staphylococcus epidermidis) was evaluated using broth dilution method, disc diffusion assay, and cell viability assay. Results: The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of Peranacid and Surfocept against the isolates were higher than those of Deconex and Microzed. The results of disk diffusion assay showed that staphylococcus strains exhibited greater inhibition zone diameter than other disinfectants at different concentrations of Deconex and Microzed. According to the results of cell viability assay, S. aureus, S. epidermidis, and S. saprophyticus isolates did not grow at three concentrations (0.5%, 1% and 2%) of Deconex, Microzed, and Peranacid, respectively. Conclusions: Deconex and Microzed had more antimicrobial properties than the 2 other agents and methicillin-resistant staphylococcus isolates had a higher resistance to both Peranacid and Surfosept.