View retraction "Relationship of Epicardial and Subcutaneous Fatty Acids With Serum Lipids and Vascular Cramps in Patients Undergoing Coronary Artery Bypass Graft"

Materials and Methods: This descriptive cross-sectional study included 42 patients within the age range of 35-65 years who underwent coronary artery bypass graft. The fatty acid profile was measured by means of gas chromatography equipment, followed by estimating the lipid parameters of serum samples using commercial kits and enzymatic method in the autoanalyzer. Finally, paraoxonase enzyme activity was evaluated by Sigma chemical paraoxon substrate.

Results: Based on the results, the amounts of saturated fatty acids (SFAs) such as meristic (14:0), palmitic (16:0), and stearic (18:0) acids of the epicardium were higher. However, the levels of unsaturated fatty acids including palmitoleic (16:1), oleic (18:1 n-9), linoleic (18:2 n-6), and linolenic acids of the epicardium were lower compared to the SAT. Further, hypertension had a positive relationship with 18:1 n-11 (r=0.349, P=0.024) while a negative relationship with 18:1 n-9 (r=0.319, P=0.041) and 18:2 n-6 (r=0.391, P=0.01) epicardial adipose tissues. Foods such as fruits and vegetables had a positive relationship with linolenic acid (18:3 n-9) and conjugated linolenic acid epicardium. Furthermore, paraoxonase enzyme activity reduced by increasing the number of vessel cramps. Moreover, body mass index was found to have a negative relationship with subcutaneous SFAs whereas a positive association with the subcutaneous palmitoleic acid (16:1 n-7).

Conclusions: In general, the findings revealed that the amounts of subcutaneous and epicardial fatty acids vary in individuals with different CADs and that both types of fatty acids and serum lipid profile are correlated with each other. Additionally, there is a relationship between fatty acids of these two tissues and serum lipid profiles and food, as well as between paraoxonase enzyme and vascular cramps.