Effects of Dehydroepiandrosterone on the Response of Ovarian Stimulation During In Vitro Fertilization Cycle in Infertile Women With Diminished Ovarian Reserve: Before and After Clinical Trials

Marzieh Zamaniyan; Bahar Farshidfar; Sepideh Peyvandi; Hamed Jafarpour; Robabeh Taheripanah; Siavash Moradi; Mojtaba Ghorbani

E-ISSN : 2148-9696

Crescent Journal of
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Jul 2019, Vol 6, Issue 3

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Original Article
Effects of Dehydroepiandrosterone on the Response of Ovarian Stimulation During In Vitro Fertilization Cycle in Infertile Women With Diminished Ovarian Reserve: Before and After Clinical Trials
Marzieh Zamaniyan^1,2, Bahar Farshidfar³, Sepideh Peyvandi^1,2, Hamed Jafarpour⁴, Robabeh Taheripanah⁵, Siavash Moradi⁶, Mojtaba Ghorbani⁷
¹Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran ²Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran ³Student Research Committee, College of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ⁴Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran ⁵Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ⁶Community Medicine Specialist, Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran ⁷Department of Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
CJMB 2019; 6: 361-368 Viewed : 3127 times Downloaded : 2875 times. Keywords : Dehydroepiandrosterone, Ovarian reserve, Anti-Mullerian Hormone, Infertility
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Abstract

Objectives: The use of dehydroepiandrosterone (DHEA) before initiating in vitro fertilization (IVF) cycles to increase the ovarian reserve is considered as one of the best therapies in women with diminished ovarian reserve (DOR). Therefore, the present study aimed to compare the effect of DHEA on women (below and above 35 years old) with DOR and to find if this therapy is useful at an earlier age. Materials and Methods: This clinical trial study was conducted on 35 infertile women with DOR who referred to Imam Khomeini hospital in Sari, Iran, during 2017. The intervention lasted for 6 weeks and DHEA tablets were used before the start of the intra-cytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle. Antral follicular counts (AFCs) and the serum levels of anti-Mullerian hormone (AMH) were estimated before and after the intervention, followed by performing the ICSI. Finally, the changes in AMH levels and AFC, the number and quality of ovum and embryos and pregnancy, along with the rates of implantation and abortion were measured as well. Results: The mean AMH levels (P = 0.02) and AFC (P < 0.001) after DHEA consumption varied significantly from those before administering the DHEA, and the increase in the AFC was more significant in the age group under 35 years (P = 0.03). In addition, these changes were more significant in body mass of less than 25 kg/m² (P = 0.04). Conclusions: In general, the supplementation of DHEA in women with insufficient ovarian capacity probably improves IVF prognosis and other parameters including AFC and AMH, especially in women under 35 years old. Further, based on different evidence, the probability of pregnancy occurrence in women is lower with increased body mass index (BMI).