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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2020, Vol 7, Issue 1
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Original Article
Protective Effect of Grape Seed Extract on DexamethasoneInduced Testicular Toxicity in Mice
Masoomeh Mohamadpour1, Raheleh Mollajani2, Farhad Sarabandi3, Fatemeh Hosseini4, Maryam Mohsenkia2, Mahboobeh Erfanizadeh4, Ali Soleimani5, Elias Kargar4, Halle Mosallaei1, Mohammadhosein Yavarahmadi6
1Research Company of Rayan Extreme Development of Enterpreneurs, Tehran, Iran
2Institute for Cognitive Science Studies, Tehran, Iran
3Islamic Azad University Tehran Medical Branch, Tehran, Iran
4Anatomy Department, Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Medical University of Dezful, Dezful, Iran. 6 Student Research Center, Baqiatallah University of Medical Science, Tehran, Iran

CJMB 2020; 7: 59–65

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Keywords : Testosterone, Follicle-stimulating hormone, Luteinizing hormone, Dexamethasone, Grape seed extract
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Objectives: Protracted and repeated exposure to glucocorticoids such as dexamethasone (Dex) may lead to reproductive dysfunction. In addition, it is a critical cause of male infertility. Grape seed extract (GSE) is an active fraction of a rich source of flavonoids and phenolic procyanidins that is used in traditional Chinese medicine. The purpose of this research was to determine the effect of GSE on testis and testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in mice with establishing dexamethasone.

Materials and Methods: To this end, 21 adult male Balb/c mice were divided into control, Dex (7 mg/kg/day i.p), and Dex+GSE (100 mg/kg/d dissolved in 0.5 mL of olive oil) groups. All the animals in the above-mentioned groups were sacrifced after 35 days, followed by evaluating testosterone, FSH, and LH levels, spontaneous acrosomal reaction, and testis stereological structure.

Results: Signifcant changes were observed in the normal range of testosterone, FSH, LH serum levels, spontaneous acrosomal reaction, as well as the number of Sertoli and Leydig cells, spermatogonia, spermatocytes, and spermatids in Dex group compared to the control rats. These parameters changed to a less extent in Dex+GSE animals compared to Dex rats as well.

Conclusions: Our fndings propose that GSE might have a curative potential on the reproductive system function and its impairment. It is regulated by Dex and reproductive-related hormones.


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Articles by Mohamadpour M
Articles by Mollajani R
Articles by Sarabandi F
Articles by Hosseini F
Articles by Mohsenkia M
Articles by Erfanizadeh M
Articles by Soleimani A
Articles by Kargar E
Articles by Mosallaei H
Articles by Yavarahmadi M


Articles by Raheleh Mollajani
Articles by Farhad Sarabandi
Articles by Fatemeh Hosseini
Articles by Maryam Mohsenkia
Articles by Ali Soleimani
Articles by Elias Kargar
Articles by Halle Mosallaei

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Arash Khaki
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