Materials and Methods: There were 30 female MS patients with mild to moderate disability, based on the McDonald criteria. They were randomly divided into 2 Pilates training (PT) and control (C) groups of equal size. The PT group followed the protocol of training 3d/wk for 8 weeks. The control group continued their routine life. Pre- and post-test of the variables in all the participants were done by one of the authors, who was blind to the groups. The anthropometric variables such as body weight (BW), body mass index (BMI), body circumferences (waist [WC], Hip [HC], mid-arm muscle [MAMC], and calf [CC]), waist to hip ratio (WHR), 7-site skinfold (chest, abdominal, thigh, triceps, subscapular, suprailiac, and midaxillary), fat percentage (FP), fat mass (FM), fat free mass (FFM), and body density (BD), functional indices consisting of balance, walking speed, endurance, and fatigue were accessed.

Results: Statistical analysis demonstrated a significant decrease in BW, BMI, WC, HC, MAMC, skin-folds of the chest, abdominal, triceps, suprailiac, FP, FM and fatigue and also increase in BD, balance, walking speed, and endurance in Pilates group (P < 0.05).

Conclusions: An 8-week mat Pilates program as non-pharmacological intervention may positively affect anthropometric variables, Functional indices and fatigue which may decline some of the outcomes of muscle weakness as one of MS complications.