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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2018, Vol 5, Issue 2
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Original Article
Effects of Echinacea purpurea Extract on Sperm Characteristics and Hematology Following Testicular Ischemia-Reperfusion Injury in Rat
Sadegh Motamedi1, Ahmad Asghari1, Alireza Jahandideh1, Gholamreza Abedi1, Pejman Mortazavi2
1Department of Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran

CJMB 2018; 5: 119-122

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Keywords : Echinacea purpurea, Ischemia/reperfusion, Testis, Rat
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Objectives: The aim of the present study was to investigate the effects of Echinacea purpurea extract on sperm characteristics following testicular ischemia/reperfusion (I/R) injury in rats.

Materials and Methods: To evaluate this hypothesis, 30 adult rats were randomly divided into 5 groups: sham operations, I/R group and 3 groups of treatment with E. purpurea extract (25, 50 and 100 mg/kg). To achieve testicular I/R, torsion (720°) of spermatic cord for 2 hours and reperfusion of the tests for 24 hours were performed. Treatment was done by intraperitoneal injection of 3 different doses of E. purpurea extract, 1 hour after ischemia. Then, the sperm count, motility and mobility were determined.

Results: There was a significant increase in sperm count, motility and mobility in treatment groups compared to I/R group (P<0.05). Treatment with E. purpurea extract (25, 50 and 100 mg/kg) significantly attenuated the adverse effect of testicular I/R on sperm mortality compared to the control group (P < 0.05). No significant difference was observed in hemograms.

Conclusions: These results confirmed beneficial effects of E. purpurea extract on sperm characteristics after testicular I/R injury in rats.


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