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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2019, Vol 6, Issue 3
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Original Article
The Effect of Low-Dose Ketamine on Prevention of Hypotension Due to Positioning After Induction of General Anesthesia in Lumbar Disc Surgery
Masoud Parish1, Fariba Nikan2, Mohammad Shimia3, Isaa Eslami1, Hojjat Pourfathi4
1Tabriz University of Medical Sciences, Tabriz, Iran
2Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3Tabriz University of Medical Sciences, Neurosurgery, East Azarbijan, Iran
43Department of Neurosurgery, Physical Medicine and Rehabilitation Research Center, Tabriz, Iran
5Department of Anesthesiology, Taleghani Hospital, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2019; 6: 388-392

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Keywords : Ketamine, Hemodynamic changes, Lumbar disc surgery, Repositioning
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Objectives: This study aimed at investigating the effect of low-dose ketamine on prevention of hypotension due to positioning after induction of general anesthesia in lumbar disc surgery.

Materials and Methods: This double-blind clinical trial was performed during a 3-month period in 2016. A random sample of 84 patients with ASA (American Society of Anesthesiologists), class I, were enrolled in the study and the impact of ketamine on prevention of hypotension due to repositioning was investigated. After induction of anesthesia and intubation, ketamine 0.5 mg/kg of body weight as well as normal saline solution, with equal volumes, were injected to the intervention and control groups, respectively. Patients were repositioned though a similar method to prone position after peak of ketamine (after 1.5 minutes), and then, systolic, diastolic, and mean of the blood pressure were measured as a baseline, once before and 1 minute after the intubation, before repositioning, immediately after repositioning the patient from supine to prone position, and then every 2 minutes until 10 minutes after repositioning.

Results: There was significant differences in means (SDs) of systolic pressure and blood pressure in the first, second, and fourth minutes after repositioning, as systolic pressure and mean of the blood pressure in ketamine group was higher than those of control group. The changes of blood pressure in ketamine group was the least amount after repositioning.

Conclusions: Ketamine can increase blood pressure, especially systolic pressure of patients, on other hand changes of blood pressure in ketamine group after repositioning was least amount.


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Articles by Parish M
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