Vitamin D Deficiency May Be a Modifiable Risk Factor in Women With Endometriosis

Marzieh Derakhshan; Maryam Derakhshan; Pegah Hedayat; Maryam Shiasi; Erfan Sadeghi

E-ISSN : 2148-9696

Crescent Journal of
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Oct 2018, Vol 5, Issue 4

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Original Article
Vitamin D Deficiency May Be a Modifiable Risk Factor in Women With Endometriosis
Marzieh Derakhshan^1,2, Maryam Derakhshan³, Pegah Hedayat³, Maryam Shiasi¹, Erfan Sadeghi⁴
¹Department of Anatomy, Tehran University of Medical Sciences, Tehran, Iran ²Gynecology and Andrology Center, Khanevadeh Hospital, Esfahan, Iran ³Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran. ⁴Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
CJMB 2018; 5: 292-296 Viewed : 3745 times Downloaded : 2469 times. Keywords : Vitamin D deficiency, Endometriosis, Calcium intake
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Abstract

Objectives: This study aimed to determine the levels of 25(OH) D in endometriosis patients and to clarify the association between the endometriosis and dietary intake of calcium and vitamin D. Materials and Methods: A total of 200 women with endometriosis as endometriosis group and 154 healthy women (control group) of reproductive age were included in this study. The plasma 25(OH) D (vitamin D3) level was measured by high-pressure liquid chromatography method in endometriosis and control (healthy) groups. Participants in these 2 groups were asked about the dietary intake of calcium and vitamin D. Results: Our result showed the association between 25(OH) D deficiency and endometriosis risk (odds ratio [OR] = 29.4, P < 0.001). The intake of dietary calcium was also inversely associated with recurrence of endometriosis. However, this association was not observed between vitamin D intake and endometriosis. Conclusions: Our results showed that the decreased level of vitamin D (VD) is associated with the endometriosis risk. Accordingly, the authors validate that vitamin D deficiency may be regarded as a predisposing factor for endometriosis. In addition, a decreased risk of endometriosis with increasing calcium (Ca) intake was observed. Therefore, using Ca as dietary supplementation may be useful in the management of endometriosis in patients.