Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2017, Vol 4, Issue 1
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
The Assessment of the Ultrastructure of Luminal Epithelium in the Endometrium After the Application of Antiprogesterone
Farzane Gafari, Fatemeh Afshari, Mohammad Taghizadieh
Department of Histopathology and Anatomy, Tabriz Branch, Islamic Azad University, Tabriz, Iran

CJMB 2017; 4: 028-031

Viewed : 1520 times
Downloaded : 1765 times.

Keywords : Endometrium, Antiprogesterone, Superovulation, Ultrastructure
Full Text(PDF) | Related Articles
Abstract
Objective: There is growing interest in the use of progesterone receptor modulators (e.g., mifepristone) for the treatment of gynecologic and other conditions. The aim of this study was to investigate the effects of antiprogesterone (RU486) on the ultrastructure of endometrial in the super ovulated mice at implantation window.

Materials and Methods: Adult male and female mice were used for the induction of pseudopregnancy. The mice were divided into two experimental and control groups. The Experimental group was further subdivided into two groups based on hormone injection: 1) antiprogesterone and 2) hyperstimulation + antiprogesterone. The control group did not get any hyperstimulation. All groups’ uteruses were collected after 4.5 days of pregnancy and were prepared for the assessment of the histological changes with light microscopy (LM) and Transition Electron Microscopy (TEM).

Results: The results showed that antiprogesterone injection decreases the height of microvilli and pinopods in the apical cell in comparison to the control group. Antiprogesterone injection increases the inflammatory cells in the lamina propria of endometrium. The histomorphometrical results indicated that endometrial luminal epithelium height in the hyperstimulation + antiprogesterone group was significantly different compared to the control group (P < 0.01).

Conclusion: These findings demonstrate that the use of mifepristone is associated with histological changes in the endometrium.

 

Cite By, Google Scholar

Google Scholar

Articles by Gafari F
Articles by Afshari F
Articles by Taghizadieh M

PubMed

Articles by Farzane Gafari
Articles by Fatemeh Afshari

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Publisher
Aras Part Medical International Press Editor-in-Chief
Arash Khaki
Deputy Editor
Zafer Akan
Published Article Statistics