Objectives: As a metabolic syndrome, type 2 diabetes mellitus (T2DM) has had a worldwide increase associated with the incidence of obesity. Vaspin acts as a new biomarker for obesity and interactive exercise. Our study aimed to survey the effect of aerobic exercise on vaspin level in the female patients with T2DM.

Materials and Methods: Forty female patients (age = 33.00 ± 8.08 years) as diagnosed with T2DM based on the International Diabetes Federation (IDF) were selected. The participants were randomly divided into exercise (E) and control groups (C). At the beginning and at the end of the study, all the variables were measured. Group E participated in 8-week training sessions, 3 days/week for 60 minutes, with an intensity of 60%-70% of maximum heart rate. The C group continued its usual life.

Results: Thirty-one subjects completed the study period ((E [n=18] and C [n=13]). Statistical analysis showed that group E had a signifcant increase in vaspin level (F = 8.888, P = 0.001) and a signifcant decrease in BW (body mass weight), BMI (body mass index), WC (waist circumference), FP (fat percentage), FM (fat mass), FFM (fat free mass), TC (total cholesterol), FBS (fast blood sugar) and insulin level, whereas there was no signifcant change in HC (hip circumference), WHR (waist to hip ratio), TG (triglyceride), HOMA-IR, and quantitative insulin sensitivity check index (QUICKI) in the E group compared with the C group (P < 0.05).

Conclusions: Our data suggested that vaspin behavior is reversed by increasing the duration and progressive stage of T2DM and its level increases following exercise and weight loss.