Association of Pulmonary Function Tests and Serum Vitamin D Levels in Asthmatics With Vitamin D Deficiency

Mahnaz Amini; Zahra Mirfeizi; Houshang Rafatpanah; Leila Ghofraniha; Shahrzad Mohammadzadeh Lari; Saeid Eslami<sup>4; 5</sup>; Habibollah Esmaily; Mostafa Abasalti

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Original Article
Association of Pulmonary Function Tests and Serum Vitamin D Levels in Asthmatics With Vitamin D Deficiency
Mahnaz Amini¹, Zahra Mirfeizi², Houshang Rafatpanah³, Leila Ghofraniha¹, Shahrzad Mohammadzadeh Lari¹, Saeid Eslami^4,5, Habibollah Esmaily⁶, Mostafa Abasalti¹
¹Lung Disease Research Center, Faculty of Medicine, Mashhad University of Medicine Sciences, Mashhad, Iran ²Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ³Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ⁴Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ⁵Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ⁶Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
CJMB 2018; 5: 021-024 Viewed : 4105 times Downloaded : 2957 times. Keywords : Asthma, Vitamin D, Respiratory function test
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Abstract

Objective: The effects of serum vitamin D levels on the evolution or severity of asthma have been widely researched; however, conflicting results have been achieved. This study was designed to evaluate the relationship between serum vitamin D levels and pulmonary function tests in asthmatic and non-asthmatic people with vitamin D deficiency.Materials and Methods: This was a prospective cross-sectional study on healthy adults and asthmatic patients. Standard spirometry and serum 25-hydroxyvitamin D test were performed for all participants.Results: Forty asthmatic patients and 40 healthy controls were tested. The mean age of participants was 42.86 ± 1.6. High prevalence of vitamin D deficiency was found in both the asthmatic and control groups. No significant correlation was found between serum vitamin D levels and spirometry parameters in either of the groups (P = 0.83). Conclusion: Serum levels of 25-hydroxyvitamin D were not correlated with the severity of asthma as evaluated by pulmonary function tests in asthmatics.