Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2019, Vol 6, Issue 1
Advanced Search
How do you find the scientific quality of the published articles on our web site?
Original Article
Comparing the Effect of Flaxseed and Fish Oils on Acute Ischemia-Reperfusion Injury in the Rat Kidney
Maryam Moghimian1, Seyed-Hosein Abtahi-Eivary2, Najme Jajarmy2, Mahdi Karimi Shahri3, Javad Adabi4, Majid Shokoohi5
1Department of Physiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
2Department of Biochemistry, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
3Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
4Clinical Laboratory, 22 Bahman Hospital, Gonabad University of Medical Sciences, Gonabad, Iran
5Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2019; 6: 006-012

Viewed : 4487 times
Downloaded : 2290 times.

Keywords : Renal ischemia-reperfusion, Oxidative stress, Fish oil, Flaxseed oil
Full Text(PDF) | Related Articles
Objectives: Polyunsaturated fatty acids (PUFAs) are useful in reducing the deleterious effects of ischemia-reperfusion (IR). This study was designed to compare the impacts of treatment with flaxseed oil (FLO), rich in linoleic and alpha-linolenic acids, and fish oil containing long PUFAs, as well as eicosapentaenoic and docosahexaenoic acids (DHAs), on IR injury in the rat kidney.

Materials and Methods: In this experimental study, 32 male Wistar rats were randomly divided into 4 groups (8 rats each) including Sham, IR, FLO, and fish oil (FO). Correspondingly, experimental groups were administered saline and flaxseed or FO at doses of 0.4 g/kg by gavage. After 4 weeks, the rats underwent right nephrectomy and 45-minute clamping of the left renal arteries followed by 24 hours reperfusion. Renal function was assessed by measuring the serum creatinine (Cr) and blood urea nitrogen (BUN) levels. The oxidative stress and serum aspartate aminotransferase (AST) activity were measured. Each kidney was sectioned into 2 equal parts. One part was used for pathological evaluations after hematoxylin-eosin staining and the other one was applied in assaying the malondialdehyde (MDA) level.

Results: Serum Cr and BUN levels, AST activity, and tissue MDA content increased in the IR group. Both FO and FLO decreased tissue MDA levels (P < 0.05 vs. IR), but could not lead to a significant reduction in the levels of the renal markers. In addition, histological damages which were increased following the IR were markedly reduced by these 2 oils.

Conclusions: Generally, FLO and FO may provide protection against IR-induced renal injury and oxidative stress. However, these effects were not significant between the 2 supplementations.


Cite By, Google Scholar

Google Scholar

Articles by Moghimian M
Articles by Abtahi-eivary S
Articles by Jajarmy N
Articles by Karimi Shahri M
Articles by Adabi J
Articles by Shokoohi M


Articles by Maryam Moghimian
Articles by Najme Jajarmy
Articles by Javad Adabi
Articles by Majid Shokoohi

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Aras Part Medical International Press Editor-in-Chief
Arash Khaki
Deputy Editor
Zafer Akan
Published Article Statistics