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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Sep 2014, Vol 1, Issue 2
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Original Article
Effect of Olea europaea Extract on Male Rats’ Reproductive Parameters
Jafar Sadegh Tabrizi1, Fatemeh Fallah Rostami2, Shahnaz Seyedi Dolatabad3, Toktam Khojasteh Bojnordi4, Seyed Shahin Ahmadi1
1Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Undersecretary For Research &Technology, Ministry of Health and Medical Education, Pediatric Neuro Rehabilitation Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran
3Health Technology Development Office, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
4Ministry of Health and Medical Education, Control of Disease Center, Tehran, Iran

CJMB 2014; 1: 059-062

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Keywords : Estradiol, Olive Leaves Extract, Rats, Testosterone
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Objective: Phytoestrogens plant compounds with biologic-estrogenic activity, structurally similar to 17-β estradiol, are first converted to heterocyclic compounds similar to estrogens in structure and then conjugated in the liver. Olive (Olea europaea), from the oleaseae family, is known as a phytoestrogen plant compound since it contains lignans and phenolic compounds. The aim of the present study was to evaluate the effect of O. europaea extract on male rats’ reproductive parameters.

Materials and Methods: In this experimental study, 40 male Wistar rats with the average weight of 200-250 g and age of 8-10 weeks, divided into 5 groups. Group 1, which called control group, received no treatment. Group 2 received normal saline and Groups 3-5 received extract at a dose of 50, 100 and 200 mg/kg/day of the olive leaves extract (1 cc), respectively. Before the administration of the first gavage and 24 h after that of the last one (i.e., in the 49th day), all the rats were weighed, and blood samples were taken from their tail vein. The blood samples were then centrifuged at 1500 rpm for 20 min, then serum was separated and stored at −80 °C for the measurement of estradiol and testosterone, using immunoassay technique.

Results: The results show a significant decrease in testosterone and estradiol level among the five groups, which is dependent on the concentration of the extract; the decrease in testosterone and estradiol is positively correlated to the concentration of the extract.

Conclusion: In conclusion, olive leaves extract significantly decreased fertility parameters in the male adult rat dose-dependently.


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