An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole

Diyardokht Rahemi<sup>1; 2</sup>; Neda Babaee; Sohrab Kazemi; Seyyed Ali Asghar Sefidgar; Ali Akbar Moghadamnia

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
An In Vitro Study of the Effect of Cinnamaldehyde on the Growth of Candida albicans Compared to Nystatin and Fluconazole
Diyardokht Rahemi^1,2, Neda Babaee¹, Sohrab Kazemi², Seyyed Ali Asghar Sefidgar³, Ali Akbar Moghadamnia²
¹Department of Oral Medicine, Babol University of Medical Sciences, Babol, Iran ²Department of Pharmacology and Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. 3Department of Mycology, Babol University of Medical Sciences, Babol, Iran
CJMB 2015; 2: 076-080 Viewed : 2682 times Downloaded : 3023 times. Keywords : Candida albicans, Cinnamaldehyde, Cinnamon, DMSO
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Abstract

Objective: Cinnamaldehyde is the main active component of cinnamon essential oil with antibacterial and antifungal effects. This in vitro study was done to investigate the effect of cinnamaldehyde on the growth of standard strain of Candida albicans (C. albicans) in comparison to nystatin suspension and fluconazole. Materials and Methods: The tests were designed for the three groups of this study namely cinnamaldehyde, fluconazole and nystatin. Standard strain of C. albicans (PTCC 5027) was used. Three methods namely disc diffusion, well diffusion and microdilution were used. Based on elevation of cinnamaldehyde concentrations, its antifungal effect was increased. Results: The minimum inhibitory concentration (MIC) of antifungal effect of cinnamaldehyde was 0.312 μl/ml. This effect is similar to the effect of 100000 IU/ml nystatin in concentration of 20 μl/ml and 1% fluconazole in concentration of 40 μl/ml. The mean (±SD) of inhibition zone diameter in concentration of 80 μl/ml for disc and well diffusion were 60.4 (±2.2) and 70 (±3.5) mm, respectively. Conclusion: These inhibition zones were larger than the zones for fluconazole and nystatin groups. According to the results, cinnamaldehyde has dose-dependent anti-C. albicans effect. In some concentrations, the cinnamaldehyde effect is similar to fluconazole and nystatin.