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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2018, Vol 5, Issue 1
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Original Article
Effect of Intraoperative Dextrose Infusion for Prevention of Postoperative Nausea and Vomiting after Diagnostic Gynecologic laparoscopy
Simin Atashkhoei1, Bahman Naghipour2, Pouya Hatami Marandi3, Abbasali Dehghani4, Hojjat Pourfathi5
1Department of Anesthesiology, Al-Zahra Hospital, Tabriz University of Medical Sciences, Iran
2Department of Anesthesiology, Fellowship of Cardiothoracic Anesthesiology, Shahid Madani Hospital,Tabriz,Iran.
Faculty of Medicine, Tabriz University of Medical Sciences
4Department of Anesthesiology, Department of Anesthesiology, Imam Reza Hospital, Tabriz University of Medical Sciences, Iran
5Department of Anesthesiology, Taleghani Hospital,University of Medical Sciences,Tabriz, Iran

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Keywords : Gynecologic Laparoscopy, PONV, Prophylaxis, Dextrose
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Objective: Laparoscopic procedures are accompany with a high occurrence of nausea and vomiting after surgery. This study aimed to evaluate the effectiveness of prophylactic intraoperative infusion of dextrose 5% in the avoidence of postoperative nausea and vomiting (PONV).

Materials and Methods: In this randomized, double-blind and placebo-controlled clinical trial, 70 ASA class I women, aged 20-40 years scheduled for diagnostic laparoscopy for infertility were studied. Following induction of anesthesia, study group (n=35) received ringer's solution10 ml/kg/h with glucose 500mg/kg (dextrose 5%) and placebo group (n=35) received ringer solution with 0.9% normal saline in the same volume intraoperatively. The incidence and severity of PONV according to a 4-point scale (0-3) in the post anesthesia care unit (PACU) and during the first 24 hours postoperatively, the first request to antiemetic, and overall antiemetic consumption were compared between two groups.

Results: The overall incidence of PONV was certainly lower in the study group compared with the placebo group (22.85% vs 45.71%; p= 0.03). Severity of PONV was significantly less in the study group (1.14±0.32) than the placebo group (2.50±0.27) (p=0.03). There were analytical compelling difference among the two groups in regard to the first time request to antiemetic after surgery (7.1±1.13 vs 5.71±1.76 hours, p=0.04) and total dose of antiemetic (metoclopramide) 60 vs 100 mg; p=0.001).There is no significant difference in perioperative blood sugar levels changes between two groups (p=0.46).

Conclusion: Intraoperative infusion of dextrose 5% was found to be an efficacious method for the prevention/reduction of PONV without significantly difference in postoperative blood sugar levels in patients undergoing diagnostic gynecologic laparoscopy.


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