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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Apr 2024, Vol 11, Issue 2
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Original Article
The Effect of Lifestyle Modification on the Recovery of Non-Alcoholic Fatty Liver Disease in Health Insurance Staff in Tabriz, Iran: A Randomized Clinical Trial
Leila Javadi1,2, Soraya Moradi1, Mohamadhossein Amirpoor1, Vahid Majidi1, Leila Nikniaz3
1National Center for Health Insurance Research, Iran Health Insurance Organization, Tehran, Iran
2Tabriz nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2024; 11: 076-082
DOI: 10.34172/cjmb.2023.4002
Viewed : 1185 times
Downloaded : 1318 times.

Keywords : Lifestyle, Modification, Recovery, NAFLD
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Objectives: Non-alcoholic fatty liver disease (NAFLD) is among the most common liver diseases. In recent years, the prevalence of fatty liver disease has been mostly attributed to obesity, an unhealthy lifestyle, and poor eating habits, which, in addition to Western countries, have also been reported in Iran. This study aimed to evaluate the effect of lifestyle modification (physical activity and diet) on the recovery of NAFLD in health insurance staff in Tabriz, Iran.

Materials and Methods: This randomized controlled clinical trial was conducted on 42 male and female NAFLD patients aged 20 to 55. The participants were randomly divided into intervention (diet along with aerobic exercise) (n=21) and control (without diet and exercise) (n=21) groups. The level of disease recovery was evaluated by measuring the level of liver enzymes (AST and ALT), liver ultrasound (to determine the degree of fatty liver), and body mass index (BMI) before and after three months of intervention. Paired and independent t-test, Mann-Whitney U test, and Wilcoxon test were performed using SPSS version 22 software. The clinical significance of the study was estimated using an epidemiological tool known as the number needed to treat (NNT).

Results: No significant difference was observed between the two groups in anthropometric and biochemical parameters, as well as fatty liver grade. However, the decrease in BMI index in the intervention group was insignificant compared to the control group. The degree of liver recovery in the intervention and control groups was calculated to be 69.9% and 33.3%, respectively. Also, the decrease in fatty liver grade in the intervention group was significant compared to the control group (P = 0.028). There was a statistically significant reduction in the severity of fatty liver disease in the intervention group at the end of the research (NNT = 3.5), meaning that for every 3.5 patients with NAFLD treated with diet and exercise for 3 months, one patient showed improvement.

Conclusions: This study showed that lifestyle modifications, such as physical activity and dietary habits, significantly affected fatty liver in NAFLD patients.


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