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E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jan 2024, Vol 11, Issue 1
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Original Article
Comparison of Clinico-Pathological Features Between Epithelial Ovarian Cancer Patients With and Without Endometriosis: A Cross-Sectional Study
Mehri Jafari Shobeiri1, Navideh Hajagaei Saeidi1, Heidar Ali Esmaeili2, Ali Dastranj Tabrizi2, Yasmin Pouraliakbar1, Parvin Mostafa-Gharabaghi1, Manizheh Sayyah-Melli1, Maryam Vaezi1, Vahideh Rahmani1, Sajjad Pourasghari1
1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2024; 11: 038-042
DOI: 10.34172/cjmb.2023.31
Viewed : 1828 times
Downloaded : 2073 times.

Keywords : Endometriosis, Ovarian epithelial cancer, Carcinoma
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Abstract
Objectives: Women with endometriosis have a high risk of developing ovarian carcinoma that may occur due to endometriosis lesions. There is few research have so far focused on the clinical factors in patients with endometriosis-associated ovarian cancer (EAOC). Accordingly, this study aimed at comparing the demographic and obstetric characteristics between ovarian cancer with and without endometriosis.

Materials and Methods: This cross-sectional study was conducted on 20 EAOC patients and 140 non-EAOC individuals who had gone under surgery from 2011-17 at Al-Zahra hospital. Clinico-pathological characteristics of the two groups including first group only had malignant epithelial ovarian tumor (non-EAOC) and second group had both malignant epithelial ovarian tumor and endometriosis (EAOC). P value less than 0.05 was considered statistically significant.

Results: EAOC cases were significantly younger (P = 0.002) and had lower number of pregnancy (P = 0.002), parity (P = 0.004), and term pregnancy (P = 0.005) than non-EAOC patients. A large proportion of EAOC cases had clear cell and endometrioid histopathology in comparison to non-EAOC individuals (P < 0.001) and most of the tumors in these cases were unilateral (P = 0.01).

Conclusions: We found that age, parity, gravidity, and term pregnancy as well as laterality and histopathologic type of epithelial ovarian cancers vary in EAOC and non-EAOC individuals. Further research is required to identify these differences.

 

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Articles by Jafari Shobeiri M
Articles by Hajagaei Saeidi N
Articles by Ali Esmaeili H
Articles by Dastranj Tabrizi A
Articles by Pouraliakbar Y
Articles by Sayyah-melli M
Articles by Vaezi M
Articles by Rahmani V
Articles by Pourasghari S

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Articles by Maryam Vaezi
Articles by Vahideh Rahmani
Articles by Sajjad Pourasghari

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Aras Part Medical International Press Editor-in-Chief
Arash Khaki
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Zafer Akan
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