Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Oct 2017, Vol 4, Issue 4
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
Functional Recovery of Transected Peripheral Nerve by Means of Microwave Irradiated Collagen Nerve Guides Filled With Chick Embryonic Cerebrospinal Fluid in Rats
Seyyed Mostafa Ghavami1, Gholam Hossein Farjah2, Hamed Shoorei3, Mohammad Amin Dolatkhah3
1Department of Radiology, Faculty of Paramedical, Tabriz University of Medical Sciences, Tabriz, Iran
2Neurophysiology Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

CJMB 2017; 4: 194–199

Viewed : 473 times
Downloaded : 250 times.

Keywords : Cerebrospinal fluid, Sciatic nerve, Collagen, Nerve injury, Microwave
Full Text(PDF) | Related Articles
Abstract
Objective(s): The physical properties of nerve guidance channel and components of the regenerating microenvironment can significantly enhance regeneration. The aim of this research was to evaluate the effect of embryo cerebrospinal fluid (ECSF) in nerve regeneration across the microwave irradiated collagen nerve guides in comparison with autograft.

Material and Methods: Under general anesthesia, the left sciatic nerve was exposed and 10 mm nerve segment defect was created in 40 adult male Sprague-Dawley rats (250-300 g). Animals were randomly divided into 4 experimental groups: repair with reversed autograft, reconstruction with collagen nerve conduit filled with ECSF, reconstruction with collagen nerve conduit filled with normal saline (NS) and sham surgery. All animals were evaluated by sciatic functional index (SFI), electrophysiology, and histopathological staining at weeks 4 and 12 after surgery.

Results: The mean SFI value of group collagen + ECSF and autograft was significantly higher than that of group NS on days 49 and 60 post-operation (P < 0.05). After 90 days after the operation, the mean nerve conduction velocity (NCV) of groups collagen + ECSF and autograft were significantly faster than NS group (P < 0.05). The regenerated nerves of groups collagen + ECSF and autograft were more mature than that of the group NS group at day 90 (P < 0.05). There was no significant difference between groups collagen + ECSF and autograft.

Conclusion: These findings showed that chick CSF in collagen guide can enhance nerve regeneration and promote functional recovery in the injured sciatic nerve of rats.

 

Cite By, Google Scholar

Google Scholar

Articles by Mostafa Ghavami S
Articles by Hossein Farjah G
Articles by Shoorei H
Articles by Amin Dolatkhah M

PubMed

Articles by Hamed Shoorei

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center
Publication Information
Publisher
Aras Part Medical International Press Editors in Chief
Arash Khaki
Editor
Zafer Akan Deputy Editor
Javadi, Leila
Published Article Statistics