Effect of Vitamin E and Selenium on Oxidative Stress and Tissue Damages Induced by Electromagnetic Fields in Immature Mice Ovarian

Seyed Mohsen Razavi; Abbas Majdi Seghinsara; Ali Abedelahi; Ramin Salimnejad; Hamid Tayefi

E-ISSN : 2148-9696

Crescent Journal of
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Original Article
Effect of Vitamin E and Selenium on Oxidative Stress and Tissue Damages Induced by Electromagnetic Fields in Immature Mice Ovarian
Seyed Mohsen Razavi¹, Abbas Majdi Seghinsara¹, Ali Abedelahi¹, Ramin Salimnejad¹, Hamid Tayefi¹
¹Department of Anatomical Science, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
CJMB 2017; 4: 120–125 Viewed : 36543 times Downloaded : 4373 times. Keywords : Electromagnetic field, Oxidative stress, Vitamin E, Selenium, Ovary
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Abstract

Objective: Electromagnetic fields (EMF) due to increased oxidative stress impact on body systems including female reproductive system and reduce fertility. The use of antioxidants decreases the amount of damage through the oxidative stress reduction. The present research studies the effect of vitamin E and selenium on oxidative stress factors level resulting from EMF in immature mice ovarian tissue. Material and Methods: In this study, 48 immature mice were randomly divided into 6 groups (n=8): (1) control, (2) EMF, (3) EMF with Vitamin E, (4) EMF with selenium, (5) EMF with vitamin E and selenium and (6) vitamin E and selenium. Finally, after 2 months the mice were killed by cervical dislocation and the ovaries were removed to evaluate tissue damages and oxidative stress factors including malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant (TAC). Results: In mice under EMF, MDA level increased and SOD, GPX and TAC decreased in ovarian tissue (P <0.05). Treatment of mice under EMF via vitamin E with selenium and by vitamin E alone significantly improved these parameters (P <0.05); though, treatment with selenium did not show any significant effect. Histological analysis exhibited the ovaries of the animals that received vitamin E and selenium showed fewer morphological changes than the EMF group. Conclusion: The results of this study indicated that vitamin E and selenium plus vitamin E significantly reduced oxidative stress in ovarian tissue of the mice exposed to EMF, but prescribing selenium alone had no significant effect.