Relation Between Cadmium and Mercury and the Deficiency of Human Sperm Nucleus

Hossein Khoramdel; Parviz Farzadinia; Mehrdad Shariati; Mohktar Mokhtari; Afshar Bargahi

E-ISSN : 2148-9696

Crescent Journal of
Medical and Biological Sciences

Main Page Aim and Scope Instructions to Authors Editorial Policies Editorial Board Authorship Agreement Form Open Access and Copyright

Jul 2020, Vol 7, Issue 3

CURRENT ISSUE ARCHIVE AHEAD OF PRINT / ACCEPTED ARTICLE MOST VIEWED ARTICLES NEWS RELATED LINKS

Advanced Search

For Author's & Reviewer's

Committee on Publication
Ethics (COPE) Flowchart

Recommendations for the Conduct

World Association of Medical Editors(WAME)

EQUATOR Resources : Reviewers

Poll

How do you find the scientific quality of the published articles on our web site?

Very good

Good

Fair

Bad

Very bad

Original Article
Relation Between Cadmium and Mercury and the Deficiency of Human Sperm Nucleus
Hossein Khoramdel¹, Parviz Farzadinia², Mehrdad Shariati¹, Mohktar Mokhtari¹, Afshar Bargahi³
¹Department of Biology, Kazerun Branch, Islamic Azad University Kazerun, Iran ²Department of Biology and Anatomical Sciences, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran. ³The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.
CJMB 2020; 7: 331-335 Viewed : 3237 times Downloaded : 2063 times. Keywords : Mercury, Cadmium, Male infertility, Chromatin condensation, Protamine, Seminal quality
Full Text(PDF) \| Related Articles
Abstract

Objectives: Mercury (Hg) and cadmium (Cd) are metals found in the environment from natural and anthropogenic sources. They are highly toxic to humans and other living beings. Most human exposures come from the consumption of contaminated seafood or occupational exposure. It has been accepted that exposure to heavy metals leads to damage the male reproduction. Therefore, the aim of this study was to evaluate the role of Hg and Cd in infertile men. Materials and Methods: In general, 62 men were included in this study among whom, 31 cases were infertile and within the age range of 23-38. The blood samples were collected to measure the concentrations of Cd and Hg in the serum using atomic adsorption spectrophotometry. In addition, semen analyses were performed according to the World Health Organization criteria, followed by sperm characteristics such as motility, head morphology, validity, and total count for at least 200 spermatozoa of each sample. Statistical analysis was done with SPSS software, version 17. Finally, the Kolmogorov-Smirnov test was used for parametric distribution. Results: A considerable level of Hg and Cd was detected in the serum of infertile men compared with the control and there was a statistical difference between them and the control group (P ≤ 0.05) Based on the results, there was a correlation between the high level of heavy metals and impairments in seminal quality. Further, the DNA damage was evaluated using chromatin condensation staining assay and the results showed a high percentage of DNA damage for infertile men in accordance with the levels of Hg and Cd (P ≤ 0.05). Conclusions: According to our results, Cd and Hg cooperate in affecting the sperm and leading to the DNA damage of the sperm.