Login Contact Us
E-ISSN : 2148-9696
Crescent Journal of
Medical and Biological Sciences
Jul 2020, Vol 7, Issue 3
Advanced Search
Title
Authors
Keyword
Poll
How do you find the scientific quality of the published articles on our web site?
Original Article
Association of Ki67 Antigen With Mitotic Count, Tumor Size, and Necrosis in Neuroendocrine Tumors of Lung
Monireh Halimi1, Taraneh Ghorbani2, Ali Dastranj Tabrizi1, Zhila Khamnian3, Sajjad Pourasghary4
1Department of Pathology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Community Medicine, National Public Health Management Centre (NPMC), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4Student Research Committee, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

CJMB 2020; 7: 398-403

Viewed : 1276 times
Downloaded : 320 times.

Keywords : Ki67, Neuroendocrine Lung Tumor, Metastasis, Tumor Grading
Full Text(PDF) | Related Articles
Abstract
Objectives: Lung cancer is the most prevalent cancer in the world and one of the five most common cancers in Iran. The level of Ki67 biomarker is related to any of the factors affecting the grading of neuroendocrine lung tumors, which is used as one of the grading criteria and a criterion for assessing and predicting survival and prognostic factors. The aim of this study was to investigate the relationship between Ki67 antigen incidence and mitotic count, necrosis, tumor size in the neuroendocrine tumors of the lung.

Materials and Methods: The samples of this analytical descriptive study, including the neuroendocrine tumors of the lung in paraffin blocks were chosen from the pathology archive of Imam Reza hospital collected during the last 10 years. Ki67 antigen immunohistochemical procedures, along with mitotic count and necrosis were performed by a collaborator pathologist. The collected data were analyzed by SPSS software and P-value less than 0.05 was considered a statistically significant level.

Results: The mean incidence of Ki67 antigen in the neuroendocrine tumors of the lung was 57.7± 6.5 and the lowest and highest incidence was 1% and 90%, respectively. In addition, the relationship between Ki67 antigen incidence and mitotic count and necrosis were significant while no significant relationship was observed between Ki67 antigen incidence and tumor size in typical carcinoid tumors.

Conclusions: Overall, the Ki67 antigen is regarded as a useful and essential tool for grading neuroendocrine lung tumors.

 

Cite By, Google Scholar

Google Scholar

Articles by Halimi M
Articles by Ghorbani T
Articles by Dastranj Tabrizi A
Articles by Khamnian Z
Articles by Pourasghary S

PubMed

Articles by Monireh Halimi
Articles by Taraneh Ghorbani
Articles by Zhila Khamnian
Articles by Sajjad Pourasghary

Submit Paper
Online Submission System
CJMB ENDNOTE ® Style Tutorials Publication Charge Women's Reproductive Health Research Center About Journal
Publication Information
Published Article Statistics